银促进的 1,6-烯炔的氧化环化反应：膦酰基芴衍生物的高区域选择性合成。
Silver-promoted oxidative cyclization of 1,6-enynes: highly regioselective synthesis of phosphorated fluorene derivatives.
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P.R. China.
出版信息
Org Lett. 2014 Nov 7;16(21):5616-9. doi: 10.1021/ol502397f. Epub 2014 Oct 15.
PMID:25317985
Abstract
A silver-promoted oxidative cyclization of 1,6-enynes with disubstituted phosphine oxides is developed for the synthesis of fluorene derivatives. The reaction proceeds with high regioselectivity by constructing one C-P bond and two C-C bonds in one step. Moreover, reduction of the pentavalent phosphine enlarges the application scope of the product.
摘要
一种银促进的 1,6-烯炔与取代膦氧化物的氧化环化反应被开发用于合成芴衍生物。该反应具有高区域选择性，通过一步构建一个 C-P 键和两个 C-C 键进行。此外，五价膦的还原扩大了产物的应用范围。
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