Thurman Angela John, McDuffie Andrea, Kover Sara T, Hagerman Randi, Channell Marie Moore, Mastergeorge Ann, Abbeduto Leonard
MIND Institute, University of California Davis, 2825 50th Street, Room 2101, Sacramento, CA, 95817, USA,
J Autism Dev Disord. 2015 Apr;45(4):1042-61. doi: 10.1007/s10803-014-2260-1.
The present study evaluated the ability of males with fragile X syndrome (FXS), nonsyndromic autism spectrum disorder (ASD), or typical development to learn new words by using as a cue to the intended referent an emotional reaction indicating a successful (excitement) or unsuccessful (disappointment) search for a novel object. Performance for all groups exceeded chance-levels in both search conditions. In the Successful Search condition, participants with nonsyndromic ASD performed similarly to participants with FXS after controlling for severity of ASD. In the Unsuccessful Search condition, participants with FXS performed significantly worse than participants with nonsyndromic ASD, after controlling for severity of ASD. Predictors of performance in both search conditions differed between the three groups. Theoretical and clinical implications are discussed.
本研究评估了患有脆性X综合征（FXS）、非综合征性自闭症谱系障碍（ASD）或发育正常的男性通过将表明成功（兴奋）或不成功（失望）寻找新物体的情绪反应作为预期指称对象的线索来学习新单词的能力。在两种搜索条件下，所有组的表现均超过了随机水平。在成功搜索条件下，在控制ASD严重程度后，非综合征性ASD参与者的表现与FXS参与者相似。在不成功搜索条件下，在控制ASD严重程度后，FXS参与者的表现明显比非综合征性ASD参与者差。三组在两种搜索条件下表现的预测因素有所不同。讨论了理论和临床意义。
