Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki, 1-1-1 Manabino, Nagayo-cho, Nagasaki 851-2195, Japan.
Dietary Cure Unit, Nagasaki Memorial Hospital, 1-11-54 Fukahori, Nagasaki 851-0301, Japan.
J Clin Biochem Nutr. 2014 Sep;55(2):135-42. doi: 10.3164/jcbn.14-30. Epub 2014 Jul 31.
Depression has been reported to be more prevalent among diabetic patients than non-diabetic individuals. Although depression and diabetes are causally and bi-directionally related, the influence of food intake frequency on depressive symptoms in diabetic patients has not been fully evaluated. This cross-sectional study analyzed data obtained from 89 patients with type 2 diabetes who completed self-administered questionnaires regarding food intake frequency, diabetic variables, physical activity and depressive states. The prevalence of a "definite" depressive state was 16.9%. The duration of diabetes, hemoglobin A1c levels, diabetic microvascular complications and physical activity levels were similar between depressed and non-depressed patients. Daily intakes of total lipids, n-6 polyunsaturated fatty acids and lipid energy ratios were significantly lower, and the carbohydrate energy ratio was significantly higher in depressed than in non-depressed patients. Coffee consumption was inversely associated with depressive symptoms, but no significant association was found between tea or green tea consumption and depressive symptoms. The logistic regression analysis showed that coffee consumption was an independent predictor of non-depressed status in diabetic patients. This might be due to biologically active compounds containing in coffee other than caffeine.
抑郁在糖尿病患者中比非糖尿病患者更为普遍。尽管抑郁和糖尿病在因果关系上是双向相关的，但食物摄入频率对糖尿病患者抑郁症状的影响尚未得到充分评估。本横断面研究分析了 89 例 2 型糖尿病患者的数据，这些患者完成了关于食物摄入频率、糖尿病变量、身体活动和抑郁状态的自我管理问卷。“明确”抑郁状态的患病率为 16.9%。抑郁和非抑郁患者的糖尿病病程、糖化血红蛋白水平、糖尿病微血管并发症和身体活动水平相似。抑郁患者的总脂质、n-6 多不饱和脂肪酸和脂质能量比的每日摄入量显著降低，而碳水化合物能量比显著升高。咖啡的摄入与抑郁症状呈负相关，但茶或绿茶的摄入与抑郁症状之间无显著相关性。逻辑回归分析显示，咖啡的摄入是糖尿病患者非抑郁状态的独立预测因素。这可能是由于咖啡中除咖啡因以外的生物活性化合物。
