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使用共光路衍射光学层析成像技术对单个人类红细胞进行分析。

Profiling individual human red blood cells using common-path diffraction optical tomography.

作者信息

Kim Youngchan, Shim Hyoeun, Kim Kyoohyun, Park HyunJoo, Jang Seongsoo, Park YongKeun

机构信息

Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.

Department of Laboratory Medicine, University of Ulsan, College of Medicine and Asan Medical Center, Seoul 138-736, Republic of Korea.

出版信息

Sci Rep. 2014 Oct 17;4:6659. doi: 10.1038/srep06659.

DOI:10.1038/srep06659
PMID:25322756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4200412/
Abstract

Due to its strong correlation with the pathophysiology of many diseases, information about human red blood cells (RBCs) has a crucial function in hematology. Therefore, measuring and understanding the morphological, chemical, and mechanical properties of individual RBCs is a key to understanding the pathophysiology of a number of diseases in hematology, as well as to opening up new possibilities for diagnosing diseases in their early stages. In this study, we present the simultaneous and quantitative measurement of the morphological, chemical, and mechanical parameters of individual RBCs employing optical holographic microtomography. In addition, it is demonstrated that the correlation analyses of these RBC parameters provide unique information for distinguishing and understanding diseases.

摘要

由于其与多种疾病的病理生理学密切相关，有关人类红细胞（RBC）的信息在血液学中具有至关重要的作用。因此，测量和了解单个红细胞的形态、化学和力学特性是理解血液学中多种疾病病理生理学的关键，也是为疾病早期诊断开辟新可能性的关键。在本研究中，我们展示了采用光学全息显微断层扫描技术对单个红细胞的形态、化学和力学参数进行同步定量测量。此外，还证明了对这些红细胞参数的相关性分析为区分和理解疾病提供了独特的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/f3b885379407/srep06659-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/df8092061189/srep06659-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/19fc03309737/srep06659-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/9d258ba13c12/srep06659-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/005b4d77ba79/srep06659-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/f3b885379407/srep06659-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/df8092061189/srep06659-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/19fc03309737/srep06659-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/9d258ba13c12/srep06659-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/005b4d77ba79/srep06659-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc02/4200412/f3b885379407/srep06659-f5.jpg

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