Layegh Parvaneh, Shoeibi Ali, Nikkhah Karim, Ghabeli Juibary Ali, Raftari Samaheh, Darbarpanah Sahar, Boroumand Reza, Azarpazhooh Mahmoudreza
Department of Radiology, Mashhad University of Medical Sciences, Mashhad, Iran.
Intervirology. 2014;57(6):365-8. doi: 10.1159/000365785. Epub 2014 Oct 15.
Chronic inflammations including infectious disorders such as HIV infection are now considered as risk factors for atherosclerosis. In this study, conducted for the first time on human subjects, human T-lymphotropic virus type 1 (HTLV-1) infection was examined as a potential risk factor for atherosclerosis.
This is a matched-pair cross-sectional study on 58 HTLV-1-infected cases and 55 healthy control subjects. The subjects did not have any major cerebrovascular risk factors. Carotid intima-media thickness (IMT) was measured for each patient using the standard protocol of the Atherosclerosis Risk in Communities (ARIC) Study.
The mean age of the subjects was 42.9 ± 10.52 years, and males made up 33% of the population. The difference between the mean IMT of the infected case group and that of the healthy control group was significant (p < 0.05).
This study indicated that the HTLV-infected individuals showed a greater carotid IMT than the age- and sex-matched control subjects. Observing no other known risk factor for atherosclerosis, we concluded that this significant difference in IMT might support the hypothesis that HTLV-1 infection is an independent risk factor for atherogenesis.
包括HIV感染等感染性疾病在内的慢性炎症现在被认为是动脉粥样硬化的危险因素。在这项首次针对人类受试者进行的研究中，对人类嗜T淋巴细胞病毒1型（HTLV-1）感染作为动脉粥样硬化的潜在危险因素进行了检测。
这是一项对58例HTLV-1感染病例和55名健康对照受试者进行的配对横断面研究。受试者没有任何主要的脑血管危险因素。使用社区动脉粥样硬化风险（ARIC）研究的标准方案为每位患者测量颈动脉内膜中层厚度（IMT）。
受试者的平均年龄为42.9±10.52岁，男性占人口的33%。感染病例组的平均IMT与健康对照组的平均IMT之间的差异具有统计学意义（p<0.05）。
本研究表明，HTLV感染个体的颈动脉IMT高于年龄和性别匹配的对照受试者。由于未观察到动脉粥样硬化的其他已知危险因素，我们得出结论，IMT的这一显著差异可能支持HTLV-1感染是动脉粥样硬化发生的独立危险因素这一假设。
