Joels Gil, Lamprecht Raphael
Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa Haifa, Israel.
Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa Haifa, Israel ; Department of Biology, Faculty of Natural Sciences, University of Haifa Haifa, Israel ; Center for Gene Manipulation in the Brain, University of Haifa Haifa, Israel ; Center for Brain and Behavior, University of Haifa Haifa, Israel.
Front Behav Neurosci. 2014 Sep 30;8:324. doi: 10.3389/fnbeh.2014.00324. eCollection 2014.
The formation of fear memory to a specific stimulus leads to subsequent fearful response to that stimulus. However, it is not apparent whether the formation of fear memory can affect other memories. We study whether specific fearful experience leading to fear memory affects different memories formation and extinction. We revealed that cued fear conditioning, but not unpaired or naïve training, inhibited the extinction of conditioned taste aversion (CTA) memory that was formed after fear conditioning training in rats. Fear conditioning had no effect on retrieval of CTA memory but specifically impaired its extinction. Extinguished fear memory, after fear extinction training, had no effect on future CTA memory extinction. Fear conditioning had no effect on CTA memory extinction if CTA memory was formed before fear conditioning. Conditioned taste aversion had no effect on fear conditioning memory extinction. We conclude that active cued fear conditioning memory can affect specifically the extinction, but not the formation, of future different memory.
对特定刺激形成恐惧记忆会导致随后对该刺激产生恐惧反应。然而，恐惧记忆的形成是否会影响其他记忆尚不清楚。我们研究导致恐惧记忆的特定恐惧经历是否会影响不同记忆的形成和消退。我们发现，线索化恐惧条件反射，而非非配对或单纯训练，会抑制大鼠在恐惧条件反射训练后形成的条件性味觉厌恶（CTA）记忆的消退。恐惧条件反射对CTA记忆的提取没有影响，但会特异性地损害其消退。在恐惧消退训练后，消退的恐惧记忆对未来CTA记忆的消退没有影响。如果CTA记忆在恐惧条件反射之前形成，恐惧条件反射对CTA记忆的消退没有影响。条件性味觉厌恶对恐惧条件反射记忆的消退没有影响。我们得出结论，活跃的线索化恐惧条件反射记忆会特异性地影响未来不同记忆的消退，而非形成。
