2010 - 2013年衰老与能量学的“40大”未来研究机遇
Aging and energetics' 'Top 40' future research opportunities 2010-2013.
作者信息
Allison David B, Antoine Lisa H, Ballinger Scott W, Bamman Marcas M, Biga Peggy, Darley-Usmar Victor M, Fisher Gordon, Gohlke Julia M, Halade Ganesh V, Hartman John L, Hunter Gary R, Messina Joseph L, Nagy Tim R, Plaisance Eric P, Powell Mickie L, Roth Kevin A, Sandel Michael W, Schwartz Tonia S, Smith Daniel L, Sweatt J David, Tollefsbol Trygve O, Watts Stephen A, Yang Yongbin, Zhang Jianhua, Austad Steven N
机构信息
Office of Energetics, University of Alabama at Birmingham, Birmingham, USA ; School of Public Health, University of Alabama at Birmingham, Birmingham, USA ; Nutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Office of Energetics, University of Alabama at Birmingham, Birmingham, USA ; School of Engineering, University of Alabama at Birmingham, Birmingham, USA ; Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, USA.
出版信息
F1000Res. 2014 Sep 12;3:219. doi: 10.12688/f1000research.5212.1. eCollection 2014.
BACKGROUND
As part of a coordinated effort to expand our research activity at the interface of Aging and Energetics a team of investigators at The University of Alabama at Birmingham systematically assayed and catalogued the top research priorities identified in leading publications in that domain, believing the result would be useful to the scientific community at large.
OBJECTIVE
To identify research priorities and opportunities in the domain of aging and energetics as advocated in the 40 most cited papers related to aging and energetics in the last 4 years.
DESIGN
The investigators conducted a search for papers on aging and energetics in Scopus, ranked the resulting papers by number of times they were cited, and selected the ten most-cited papers in each of the four years that include 2010 to 2013, inclusive.
RESULTS
Ten research categories were identified from the 40 papers. These included: (1) Calorie restriction (CR) longevity response, (2) role of mTOR (mechanistic target of Rapamycin) and related factors in lifespan extension, (3) nutrient effects beyond energy (especially resveratrol, omega-3 fatty acids, and selected amino acids), 4) autophagy and increased longevity and health, (5) aging-associated predictors of chronic disease, (6) use and effects of mesenchymal stem cells (MSCs), (7) telomeres relative to aging and energetics, (8) accretion and effects of body fat, (9) the aging heart, and (10) mitochondria, reactive oxygen species, and cellular energetics.
CONCLUSION
The field is rich with exciting opportunities to build upon our existing knowledge about the relations among aspects of aging and aspects of energetics and to better understand the mechanisms which connect them.
背景
作为在衰老与能量学交叉领域拓展研究活动的协同努力的一部分，阿拉巴马大学伯明翰分校的一组研究人员系统地分析并编目了该领域主要出版物中确定的首要研究重点，认为这一结果将对广大科学界有用。
目的
确定过去4年中与衰老和能量学相关的40篇被引用次数最多的论文中所倡导的衰老与能量学领域的研究重点和机遇。
设计
研究人员在Scopus数据库中搜索有关衰老和能量学的论文，根据被引用次数对所得论文进行排名，并在包括2010年至2013年（含）的四年中每年选取十篇被引用次数最多的论文。
结果
从这40篇论文中确定了十个研究类别。这些类别包括：（1）卡路里限制（CR）的长寿反应；（2）雷帕霉素的作用机制靶点（mTOR）及相关因子在寿命延长中的作用；（3）能量之外的营养物质效应（尤其是白藜芦醇、ω-3脂肪酸和特定氨基酸）；（4）自噬与长寿和健康的关系；（5）与衰老相关的慢性病预测指标；（6）间充质干细胞（MSCs）的应用及效应；（7）端粒与衰老和能量学的关系；（8）体脂的积累及效应；（9）衰老心脏；（10）线粒体、活性氧与细胞能量学。
结论
该领域有很多令人兴奋的机会，可在我们现有关于衰老各方面与能量学各方面之间关系的知识基础上进一步拓展，并更好地理解连接它们的机制。
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