Wakabayashi H, Shinzawa H, Toda H, Takahashi T, Ishikawa M
Second Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Gastroenterol Jpn. 1989 Dec;24(6):676-84. doi: 10.1007/BF02774167.
In rats with experimental liver injuries and humans with various liver diseases, fluorescence from the liver surface after intravenous injection of 10% fluorescein-sodium was investigated. Our improved fluorescence laparoscopy allowed clear fluorescent images. In normal rats and in cases of nonspecific reactive hepatitis, fluorescence was first found in the portal area of the liver surface; it was then observed spreading into the lobules towards the central veins. In damaged livers of both rats and human, bright fluorescence was observed in arterioles, necrotic foci, and fibrotic areas on the liver surface. The patterns of fluorescence which appeared in the early phase after intravenous injection of fluorescein-sodium seemed to reflect the shapes and distribution patterns of the portal areas. These results suggest that observations with improved fluorescence laparoscopy are useful for diagnoses of liver diseases.
在实验性肝损伤大鼠和患有各种肝脏疾病的人类中，研究了静脉注射10%荧光素钠后肝脏表面的荧光情况。我们改进的荧光腹腔镜检查可获得清晰的荧光图像。在正常大鼠和非特异性反应性肝炎病例中，首先在肝脏表面的门静脉区域发现荧光；随后观察到荧光向小叶内朝中央静脉扩散。在大鼠和人类的受损肝脏中，在肝脏表面的小动脉、坏死灶和纤维化区域观察到明亮的荧光。静脉注射荧光素钠后早期出现的荧光模式似乎反映了门静脉区域的形状和分布模式。这些结果表明，改进的荧光腹腔镜检查对肝脏疾病的诊断有用。
