Mehendiratta Monica, Solomon Monica Charlotte, Boaz Karen, Guddattu Vasudeva, Mohindra Aashima
Department of Oral Pathology, Sudha Rustagi Dental College, Faridabad, Haryana, India.
Department of Oral Pathology, Manipal College of Dental Sciences, Manipal, India.
J Oral Maxillofac Pathol. 2014 May;18(2):217-22. doi: 10.4103/0973-029X.140753.
Recent studies have indicated that although malignant cells at the invasive tumor front, bare morphological resemblance to the cells at central portion of the tumor, their molecular character differs significantly. E-cadherin is a cell-cell adhesion molecule that connects epithelial cells. This study attempts to correlate the E-cadherin expression at the invasive tumor front with tumor differentiation along with its clinico-pathological parameters.
Immunohistochemical staining with E-cadherin was carried out on archival cases of primary oral squamous cell carcinomas (n = 30). The E-cadherin expression at the invasive tumor front was analyzed and was linked to clinico-pathological parameters including patient prognosis.
The downregulation of E-cadherin expression at the invasive tumor edge when compared with patient's prognosis yielded a significant correlation (P = 0.041) but its correlation with the degree of differentiation determined was not significant (P = 0.27). Also, its association with tumor size and lymph node status was negative.
Loss of E-cadherin expression at the invasive tumor front is an important event in the progression of oral squamous cell carcinomas. Tumors with a loss of expression of E-cadherin are those which had a poor prognosis.
近期研究表明，尽管侵袭性肿瘤前沿的恶性细胞在形态上与肿瘤中心部分的细胞相似，但其分子特征却有显著差异。E-钙黏蛋白是一种连接上皮细胞的细胞间黏附分子。本研究旨在将侵袭性肿瘤前沿的E-钙黏蛋白表达与肿瘤分化及其临床病理参数相关联。
对30例原发性口腔鳞状细胞癌存档病例进行E-钙黏蛋白免疫组织化学染色。分析侵袭性肿瘤前沿的E-钙黏蛋白表达，并将其与包括患者预后在内的临床病理参数相关联。
与患者预后相比，侵袭性肿瘤边缘E-钙黏蛋白表达下调具有显著相关性（P = 0.041），但其与确定的分化程度的相关性不显著（P = 0.27）。此外，其与肿瘤大小和淋巴结状态的关联为阴性。
侵袭性肿瘤前沿E-钙黏蛋白表达缺失是口腔鳞状细胞癌进展中的一个重要事件。E-钙黏蛋白表达缺失的肿瘤预后较差。
