Department of Urology, Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 200127 China ; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China ; Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China ; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA ; Program in Developmental Biology, Baylor College of Medicine, Houston, TX USA.
Cell Biosci. 2014 Oct 1;4(1):58. doi: 10.1186/2045-3701-4-58. eCollection 2014.
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily. Extensive evidence has indicated that COUP-TFII plays a critical and indispensable role in cell-fate specification, organogenesis, angiogenesis, and metabolism as well as in a variety of diseases. Recent studies obtained from genetically engineered mouse models (GEM) and patient specimen analysis indicate that COUP-TFII is also important for tumor progression and metastasis. In this article, we will comprehensively review the oncogenic roles of COUP-TFII within the tumor microenvironment and tumor cells and delineate the mechanism by which COUP-TFII contributes to tumorigenesis. The applicability of current data to our understanding of the role of COUP-TFII in cancer and the potential therapeutic implications will also be discussed.
鸡卵清蛋白上游启动子转录因子 II（COUP-TFII）属于甾体/甲状腺激素受体超家族。大量证据表明，COUP-TFII 在细胞命运特化、器官发生、血管生成和代谢以及各种疾病中发挥着关键和不可或缺的作用。最近来自基因工程小鼠模型（GEM）和患者标本分析的研究表明，COUP-TFII 对肿瘤的进展和转移也很重要。在本文中，我们将全面综述 COUP-TFII 在肿瘤微环境和肿瘤细胞中的致癌作用，并阐述 COUP-TFII 促进肿瘤发生的机制。还将讨论当前数据对我们理解 COUP-TFII 在癌症中的作用的适用性以及潜在的治疗意义。
