阿切人群中HLA - DR4单倍型与结核菌素皮肤试验反应之间的关联。

Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population.

作者信息

Lindenau J D, Guimarães L S P, Hurtado A M, Hill K R, Tsuneto L T, Salzano F M, Petzl-Erler M L, Hutz M H

机构信息

Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

出版信息

Tissue Antigens. 2014 Nov;84(5):479-83. doi: 10.1111/tan.12451.

DOI:10.1111/tan.12451

PMID:25329634

Abstract

The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB104, DQA103 and DQB1*03:02 were associated with TST response in this population.

摘要

人类白细胞抗原（HLA）系统在免疫反应调节中起主要作用，因为它参与抵御病原体。与结核病（TB）关联的证据在HLA II类基因方面比I类基因更为一致。结核病在南美洲原住民中很重要，不仅因为其在区域人口减少方面的历史作用，还因为它仍然广泛存在。本研究的目的是评估76名阿切族人群中HLA II类等位基因、单倍型和基因型与结核菌素皮肤试验反应（TST）之间的关联。采用泊松回归评估风险基因型。DRB104、DQA103和DQB1*03:02与该人群的TST反应相关。