Ajslev Teresa A, Ängquist Lars, Silventoinen Karri, Baker Jennifer L, Sørensen Thorkild I A
Institute of Preventive Medicine, Frederiksberg and Bispebjerg Hospital, Frederiksberg, Denmark.
Population Research Unit, Department of Social Research, University of Helsinki, Helsinki, Finland.
PLoS One. 2014 Oct 17;9(10):e109932. doi: 10.1371/journal.pone.0109932. eCollection 2014.
The intergenerational resemblance in body mass index may have increased during the development of the obesity epidemic due to changes in environment and/or expression of genetic predisposition.
This study investigates trends in intergenerational correlations of childhood body mass index (BMI; kg/m2) during the emergence of the obesity epidemic.
The study population was derived from the Copenhagen School Health Records Register, which includes height and weight measurements since birth year 1930. Mothers and fathers with BMIs available at ages 7 (n = 25,923 and n = 20,972) or 13 years (n = 26,750 and n = 21,397), respectively, were linked through the civil registration system introduced in 1968 to their children with BMIs available at age 7 years. Age- and sex-specific BMI z-scores were calculated. Correlations were estimated across eight intervals of child birth years (1952-1989) separately by sex. Trends in these correlations were examined. Whereas the mother-child correlations reflected the biological relationship, a likely decline in the assignment of non-biological fathers through the registration system across time must be considered when interpreting the father-child correlations.
The BMI correlations between mothers and sons ranged from 0.29-0.36 and they decreased marginally, albeit significantly across time at ages 7-7 years (-0.002/year, p = 0.006), whereas those at 13-7 years remained stable (<0.0004/year, p = 0.96). Mother-daughter correlations ranged from 0.30-0.34, and they were stable at ages 7-7 years (0.0001/year, p = 0.84) and at 13-7 years (0.0004/year, p = 0.56). In contrast, father-son correlations increased significantly during this period, both at ages 7-7 (0.002/year, p = 0.007) and at ages 13-7 years (0.003/year, p<0.001), whereas the increase in father-daughter correlations were insignificant both at ages 7-7 (0.001/year, p = 0.37) and at ages 13-7 years (0.001/year, p = 0.18).
During the obesity epidemics development, the intergenerational resemblance with mothers remained stable, whereas the father-child BMI resemblance increased, possibly reflecting changes in family relationships, and unlikely to have influenced the epidemic.
由于环境变化和/或遗传易感性的表达，在肥胖流行的发展过程中，体重指数的代际相似性可能有所增加。
本研究调查肥胖流行出现期间儿童体重指数（BMI；kg/m²）代际相关性的趋势。
研究人群来自哥本哈根学校健康记录登记册，其中包括自1930年出生以来的身高和体重测量数据。分别有7岁（n = 25,923和n = 20,972）或13岁（n = 26,750和n = 21,397）时BMI数据的母亲和父亲，通过1968年引入的民事登记系统与7岁时BMI数据可用的子女相联系。计算了年龄和性别特异性的BMI z评分。按性别分别估计了八个儿童出生年份区间（1952 - 1989年）的相关性。研究了这些相关性的趋势。虽然母子相关性反映了生物学关系，但在解释父子相关性时，必须考虑随着时间推移通过登记系统非生物学父亲的认定可能减少的情况。
母亲与儿子之间的BMI相关性在0.29 - 0.36之间，在7 - 7岁时随时间略有下降，尽管具有统计学意义（-0.002/年，p = 0.006），而在13 - 7岁时保持稳定（<0.0004/年，p = 0.96）。母亲与女儿之间的相关性在0.30 - 0.34之间，在7 - 7岁时（0.0001/年，p = 0.84）和13 - 7岁时（0.0004/年，p = 0.56）均保持稳定。相比之下，在此期间父子相关性显著增加，在7 - 7岁时（0.002/年，p = 0.007）和13 - 7岁时（0.003/年，p<0.001）均如此，而父女相关性在7 - 7岁时（0.001/年，p = 0.37）和13 - 7岁时（0.001/年，p = 0.18）的增加均不显著。
在肥胖流行的发展过程中，与母亲的代际相似性保持稳定，而父子BMI相似性增加，这可能反映了家庭关系的变化，且不太可能对肥胖流行产生影响。
