Gong Weiqun, Feng Yunhai, Yan Ping, Li Shuijun, Yu Chen, Zhou Xueying, Xu Feng, Zhang Dan, Ren Xiabin, Zhou Jing, Jiang Yongfeng
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Jul;28(14):1031-3.
To investigate the effect of nasal instillation of vitamin D3 on patients with allergic rhinitis symptoms including nasal itching, sneezing, clear nasal discharge, and nasal congestion.
Thirty subjects with allergic rhinitis proved by skin prick test (SPT) and 30 subjects with deviated septum alone were recrui ted and administrated with 300 000 IU of vitamin D3 by nasal instillation weekly. Seven days after the intervention, the four major symptoms including nasal itching, sneezing, clear nasal discharge, and nasal congestion were evaluated by score.
After intranasal instillation of vitamin D3, the symptoms in allergic rhinitis group in cluding nasal itching, sneezing, nasal discharge and nasal congestion, and serum 25-hydroxyvitamin D level has statistical differences (P < 0.05).
Vitamin D3 could be well absorbed through nasal mucosa. It demonstrated to have significantly effect on serum 25-hydroxyvitamin D to improve the symptoms for patients with allergic rhinitis. Vitamin D3 may be a kind of adjuvant therapy for prevention and treatment of allergic rhinitis.
探讨滴鼻给予维生素D3对变应性鼻炎患者鼻痒、喷嚏、清涕、鼻塞症状的影响。
招募30例经皮肤点刺试验（SPT）确诊的变应性鼻炎患者和30例单纯鼻中隔偏曲患者，每周滴鼻给予30万国际单位维生素D3。干预7天后，对鼻痒、喷嚏、清涕、鼻塞4项主要症状进行评分。
变应性鼻炎组滴鼻给予维生素D3后，鼻痒、喷嚏、流涕、鼻塞症状及血清25-羟维生素D水平有统计学差异（P<0.05）。
维生素D3可经鼻黏膜良好吸收。其对血清25-羟维生素D有显著影响，可改善变应性鼻炎患者的症状。维生素D3可能是一种防治变应性鼻炎的辅助治疗方法。
