Geldof B A, Roesyanto I D, van Joost T
Department of Dermatology and Venereology, Erasmus University Rotterdam, The Netherlands.
Contact Dermatitis. 1989 Nov;21(5):312-5. doi: 10.1111/j.1600-0536.1989.tb04749.x.
Sensitization by para-tertiary-butylphenolformaldehyde resin (PTBP-FR), which is particularly useful as a leather glue, has been known for 30 years. We retrospectively studied the clinical aspects of those patients with a PTBP-FR allergy among 1966 patients in whom contact dermatitis was confirmed by patch testing. A positive patch test to PTBP-FR was present in 30 patients (1.5%), 24 of whom were women. Exposure to PTBP-FR as a cause of the dermatitis was "certain" in 7, "very likely" in 6 and "unclear" in 17. 67.7% of the patients had a multiple allergy. In 43.3% of the patients, a history of atopy was found. No clear association of PTBP-FR sensitization with allergies to phenolformaldehyde resin (P-FR) or free para-tertiary-butylphenol (PTBP) emerged in this group of 30 patients. This study supports the hypothesis that PTBP-FR and P-FR do not contain the same sensitizers. Follow-up of 26 of the 30 patients showed a favourable course, dependent on identification of the source of exposure, avoidance of further contact and absence of sensitization to multiple allergens.
对作为皮革胶水特别有用的对叔丁基苯酚甲醛树脂（PTBP - FR）致敏已有30年的认知。我们回顾性研究了1966例经斑贴试验确诊为接触性皮炎患者中对PTBP - FR过敏患者的临床情况。30例患者（1.5%）斑贴试验对PTBP - FR呈阳性，其中24例为女性。作为皮炎病因接触PTBP - FR的情况，7例“确定”，6例“很可能”，17例“不清楚”。67.7%的患者有多种过敏。43.3%的患者有特应性病史。在这30例患者中，未发现PTBP - FR致敏与对酚醛树脂（P - FR）或游离对叔丁基苯酚（PTBP）过敏有明确关联。本研究支持PTBP - FR和P - FR不含相同致敏原的假说。对30例患者中的26例进行随访，结果显示病情转归良好，这取决于接触源的识别、避免进一步接触以及对多种变应原无致敏。
