对叔丁基苯酚甲醛树脂致敏
Sensitization to para-tertiary-butylphenolformaldehyde resin.
作者信息
Massone L, Anonide A, Borghi S, Usiglio D
机构信息
Department of Dermatology, Galliera Hospital, Genoa, Italy.
出版信息
Int J Dermatol. 1996 Mar;35(3):177-80. doi: 10.1111/j.1365-4362.1996.tb01634.x.
BACKGROUND
Phenolformaldehyde resins, especially the para-tertiary-butylphenolformaldehyde resin (PTBP-FR), are widely used in industry and in numerous materials of everyday use, such as glues, adhesives, or inks. They can cause many occupational and nonoccupational cases of dermatitis.
PATIENTS AND METHODS
Forty-one patients with positive patch test results to PTBP-FR were selected for this study. They were patch-tested with a series of chemically related compounds and cross-reactions were noted.
RESULTS
Phenolformaldehyde resin (PF-R) was frequently positive (65.8%), whereas other compounds gave a much smaller number of positive results. Cases of occupational exposure (24.4%), location of the dermatitis (hands were involved in 46.3% of cases), and possible sources of exposure (shoes were the responsible agent in 12.2% of cases) were evaluated.
CONCLUSIONS
Phenolformaldehyde resins are an important cause of contact dermatitis and must be studied chemically and clinically to improve the prognosis of sensitized patients.
背景
酚醛树脂，尤其是对叔丁基酚醛树脂（PTBP - FR），广泛应用于工业及众多日常用品中，如胶水、粘合剂或油墨。它们可导致许多职业性和非职业性的皮炎病例。
患者与方法
本研究选取了41例对PTBP - FR斑贴试验结果呈阳性的患者。他们接受了一系列化学相关化合物的斑贴试验，并记录交叉反应情况。
结果
酚醛树脂（PF - R）常常呈阳性（65.8%），而其他化合物呈阳性的结果要少得多。对职业暴露病例（24.4%）、皮炎发生部位（手部受累占46.3%的病例）以及可能的暴露源（鞋子是12.2%病例的致病因素）进行了评估。
结论
酚醛树脂是接触性皮炎的一个重要病因，必须从化学和临床方面进行研究，以改善致敏患者的预后。
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