Kim Jeongseon, Choi Wook Jin, Jeong Seung Hwa
Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Goyang, Korea.
J Cancer Prev. 2013 Sep;18(3):193-200. doi: 10.15430/jcp.2013.18.3.193.
Adverse health outcomes are often seen in breast cancer survivors due to prolonged treatment with side effects such as loss of energy and lack of physical strength. Physical activity (PA) has been proposed as an adequate intervention for women with breast cancer. Therefore, this review summarizes the effects of physical activity on breast cancer survivors after diagnosis. We searched electronic databases including PubMed, Medline, Embase, and Google Scholar for articles published between January 1980 and May 2013. We included a variety of studies such as randomized controlled trials, pilot studies, and clinical trials. We reviewed these studies for three major outcomes: changes in breast cancer mortality, physiological functions, and metabolic biomarkers. Of 127 studies, 33 studies were selected as eligible studies. These studies included physical activities of varying type, duration, frequency, and intensity (e.g., aerobic and resistance training) and examined changes in three major outcomes among breast cancer survivors. Many of the studies suggest that breast cancer survivors benefit from engaging in physical activity, but some studies were limited in their ability to provide adequate evidence due to relatively small sample sizes, short intervention periods, or high attrition. Based on epidemiological evidence, recent studies demonstrated that those breast cancer survivors who engaged in physical activity significantly lowered their risk of breast cancer mortality and improved their physiological and immune functions. Some studies demonstrated changes in metabolic biomarkers such as insulin and insulin-like growth factors. However, further investigation is required to support these findings because these results are not consistent.
由于长期治疗带来诸如精力丧失和体力缺乏等副作用，乳腺癌幸存者常常出现不良健康后果。体育活动（PA）已被提议作为对乳腺癌女性的一种适当干预措施。因此，本综述总结了体育活动对乳腺癌幸存者确诊后的影响。我们在包括PubMed、Medline、Embase和谷歌学术等电子数据库中搜索了1980年1月至2013年5月发表的文章。我们纳入了各种研究，如随机对照试验、试点研究和临床试验。我们针对三个主要结果对这些研究进行了综述：乳腺癌死亡率的变化、生理功能和代谢生物标志物。在127项研究中，33项研究被选为符合条件的研究。这些研究包括不同类型、持续时间、频率和强度的体育活动（如有氧运动和抗阻训练），并研究了乳腺癌幸存者中三个主要结果的变化。许多研究表明，乳腺癌幸存者从参与体育活动中获益，但一些研究由于样本量相对较小、干预期短或损耗率高，在提供充分证据的能力方面存在局限。基于流行病学证据，近期研究表明，那些参与体育活动的乳腺癌幸存者显著降低了乳腺癌死亡风险，并改善了其生理和免疫功能。一些研究表明代谢生物标志物如胰岛素和胰岛素样生长因子发生了变化。然而，由于这些结果不一致，需要进一步调查来支持这些发现。
