太极拳锻炼对乳腺癌幸存者健康相关生活质量和生物标志物的影响。
Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan.
机构信息
James P. Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA.
出版信息
J Cancer Surviv. 2012 Jun;6(2):146-54. doi: 10.1007/s11764-011-0205-7. Epub 2011 Dec 10.
INTRODUCTION
Breast cancer survivors experience diminished health-related quality of life (HRQOL). We report on the influence of tai chi chuan exercise (TCC) on HRQOL and explore associations between changes in HRQOL and biomarkers.
METHODS
Breast cancer survivors (N = 21) were randomly assigned to TCC or standard support therapy (SST) for 12 weeks (three times/week; 60 min/session). Interleukin-6, interleukin-8 (IL-8), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein (IBFBP)-1, IGFBP-3, glucose, insulin, and cortisol were measured pre- and postintervention. Overall HRQOL and subdomains were assessed at preintervention (T1), midintervention (T2) and postintervention (T3) and biomarkers at T1 and T3.
RESULTS
The TCC group improved in total HRQOL (T1-T2:CS = 8.54, P = 0.045), physical functioning (T1-T2:CS = 1.89, P = 0.030), physical role limitations (T1-T2 CS = 1.55, P = 0.023), social functioning (T1-T3:CS = 1.50, P = 0.020), and general mental health (T1-T2:CS = 2.67, P = 0.014; T1-T3:CS = 2.44, P = 0.019). The SST improved in social functioning (T1-T2:CS = 0.64, P = 0.043) and vitality (T1-T2:CS = 0.90, P = 0.01). There were relationships between changes in IGF-1 and overall HRQOL (r = -0.56; P < 0.05), physical role limitation (r = -0.68; P < 0.05), and social functioning (r = -0.56; P < 0.05). IGFBP-1 changes were associated with physical role limitations changes (r = 0.60; P < 0.05). IGFBP-3 changes were associated with physical functioning changes (r = 0.46; P ≤ 0.05). Cortisol changes were associated with changes in physical role limitations (r = 0.74; P < 0.05) and health perceptions (r = 0.46; P < 0.05). Glucose changes were associated with emotional role limitation changes (r = -0.70; P < 0.001). IL-8 changes were associated with emotional role limitation changes (r = 0.59; P < 0.05).
DISCUSSION/CONCLUSIONS: TCC may improve HRQOL by regulating inflammatory responses and other biomarkers associated with side effects from cancer and its treatments.
IMPLICATIONS FOR CANCER SURVIVORS
TCC may be an intervention capable of improving HRQOL in breast cancer survivors.
简介
乳腺癌幸存者的健康相关生活质量（HRQOL）下降。我们报告了太极拳锻炼（TCC）对 HRQOL 的影响，并探讨了 HRQOL 变化与生物标志物之间的关系。
方法
将 21 名乳腺癌幸存者随机分配到 TCC 或标准支持治疗（SST）组，进行 12 周的治疗（每周 3 次；每次 60 分钟）。在干预前后测量白细胞介素-6、白细胞介素-8（IL-8）、胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子结合蛋白-1（IGFBP-1）、IGFBP-3、葡萄糖、胰岛素和皮质醇。在干预前（T1）、干预中期（T2）和干预后（T3）评估总体 HRQOL 和子域，在 T1 和 T3 评估生物标志物。
结果
TCC 组在总 HRQOL（T1-T2：CS=8.54，P=0.045）、身体机能（T1-T2：CS=1.89，P=0.030）、身体角色限制（T1-T2：CS=1.55，P=0.023）、社会功能（T1-T3：CS=1.50，P=0.020）和一般心理健康（T1-T2：CS=2.67，P=0.014；T1-T3：CS=2.44，P=0.019）方面有所改善。SST 在社会功能（T1-T2：CS=0.64，P=0.043）和活力（T1-T2：CS=0.90，P=0.01）方面有所改善。IGF-1 和整体 HRQOL（r=-0.56；P<0.05）、身体角色限制（r=-0.68；P<0.05）和社会功能（r=-0.56；P<0.05）的变化与 IGF-1 的变化之间存在关系。IGFBP-1 变化与身体角色限制变化相关（r=0.60；P<0.05）。IGFBP-3 变化与身体功能变化相关（r=0.46；P≤0.05）。皮质醇变化与身体角色限制变化（r=0.74；P<0.05）和健康感知变化（r=0.46；P<0.05）相关。葡萄糖变化与情感角色限制变化相关（r=-0.70；P<0.001）。IL-8 变化与情感角色限制变化相关（r=0.59；P<0.05）。
讨论/结论：TCC 可能通过调节与癌症及其治疗相关副作用相关的炎症反应和其他生物标志物来改善 HRQOL。
对癌症幸存者的影响
TCC 可能是一种能够改善乳腺癌幸存者 HRQOL 的干预措施。
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