Suthiwong Jittra, Pitchuanchom Siripit, Wattanawongdon Wareeporn, Hahnvajanawong Chariya, Yenjai Chavi
Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, and §Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University , Khon Kaen 40002, Thailand.
J Nat Prod. 2014 Nov 26;77(11):2432-7. doi: 10.1021/np500476h. Epub 2014 Oct 22.
Five new compounds, including pteroloterins A-C (1, 3, and 4), 1β-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 ± 0.18 μM and showed no activity against normal cells.
从大叶云实的根皮中分离出5个新化合物，包括大叶云实蝶呤A - C（1、3和4）、1β - 乙酰氧基大苞山柑素C（2）和8aα - 羟基荜澄茄醛（5），以及11个已知化合物。对所有化合物进行了抗胆管癌细胞系的细胞毒性评估。化合物9对KKU - M139细胞系显示出较弱的细胞毒性，IC50值为23.24±0.18μM，对正常细胞无活性。
