Ruiz-Pérez Nancy J, Arriaga-Alba Myriam, Sánchez-Navarrete Jaime, Camacho-Carranza Rafael, Hernández-Ojeda Sandra, Espinosa-Aguirre Javier J
Hospital Juárez de México- División de Investigación.
Instituto de Investigaciones Biomédicas, UNAM. Ciudad Universitaria, apartado postal 70228, México, D.F., 04510 México.
Sci Rep. 2014 Oct 23;4:6743. doi: 10.1038/srep06743.
The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of H. inuloides could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with in vivo systems will afford information about H. inuloides beneficial and detrimental properties.
之前已有关于异叶泽兰抗氧化和保肝作用的报道，然而其作为一种可能的化学预防剂的用途尚未见文献记载。本研究的目的是使用艾姆斯试验评估异叶泽兰提取物的诱变和抗诱变活性。甲醇提取物和丙酮提取物在TA98菌株中具有诱变性，但在TA100或TA102菌株中无诱变性。另一方面，甲醇提取物降低了诺氟沙星、苯并[a]芘和2-氨基蒽的诱变性。甲醇提取物中的主要成分之一槲皮素也呈现出诱变/抗诱变双重效应，并且是细胞色素P450（CYP）1A的抑制剂。异叶泽兰的抗遗传毒性特性可能归因于先前报道的抗氧化特性以及槲皮素介导的CYP抑制作用。使用体内系统的进一步研究将提供有关异叶泽兰有益和有害特性的信息。
