肥胖对心肌和主动脉的结构及代谢影响
Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta.
作者信息
Rider Oliver J, Lewis Andrew J M, Neubauer Stefan
机构信息
University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, UK.
出版信息
Obes Facts. 2014;7(5):329-338. doi: 10.1159/000368429. Epub 2014 Oct 23.
Abstract
Obesity per se is a recognized risk factor for cardiovascular disease exerting independent adverse effects on the cardiovascular system. Despite this well documented link, the mechanisms by which obesity modulates cardiovascular risk are not well understood. Obesity is linked to a wide variety of cardiac changes, from subclinical diastolic dysfunction to end stage systolic heart failure. In addition, obesity causes changes in cardiac metabolism that make ATP production and utilization less efficient producing functional consequences that are linked to the increased rate of heart failure in this population. This review focuses on the cardiovascular structural and metabolic remodelling that occurs in obesity with and without co-morbidities and the potential links to increased mortality in this population. © 2014 S. Karger GmbH, Freiburg.
摘要
肥胖本身就是公认的心血管疾病风险因素，会对心血管系统产生独立的不良影响。尽管这种关联已有充分记录，但肥胖调节心血管风险的机制仍未完全明确。肥胖与多种心脏变化相关，从亚临床舒张功能障碍到终末期收缩性心力衰竭。此外，肥胖会导致心脏代谢发生变化，使ATP的产生和利用效率降低，从而产生与该人群心力衰竭发生率增加相关的功能后果。本综述重点关注肥胖患者无论有无合并症时发生的心血管结构和代谢重塑，以及该人群死亡率增加的潜在关联。© 2014 S. Karger GmbH, Freiburg。
相似文献
1
Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta.肥胖对心肌和主动脉的结构及代谢影响
Obes Facts. 2014;7(5):329-338. doi: 10.1159/000368429. Epub 2014 Oct 23.
2
Myocardial substrate metabolism in obesity.肥胖患者的心肌底物代谢。
Int J Obes (Lond). 2013 Jul;37(7):972-9. doi: 10.1038/ijo.2012.170. Epub 2012 Oct 16.
3
Effects of Obesity on Cardiovascular Hemodynamics, Cardiac Morphology, and Ventricular Function.肥胖对心血管血流动力学、心脏形态及心室功能的影响。
Curr Obes Rep. 2016 Dec;5(4):424-434. doi: 10.1007/s13679-016-0235-6.
4
[Obesity and cardiac failure].[肥胖与心力衰竭]
Arch Mal Coeur Vaiss. 2005 Jan;98(1):39-45.
5
6
The incremental prognostic value of echocardiography in asymptomatic stage a heart failure.超声心动图在无症状 A 期心力衰竭中的预后增值。
J Am Soc Echocardiogr. 2010 Oct;23(10):1025-34. doi: 10.1016/j.echo.2010.06.017. Epub 2010 Jul 24.
7
Abnormal myocardial deformation properties in obese, non-hypertensive children: an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study.肥胖非高血压儿童的心肌变形特性异常：一项动态血压监测、标准超声心动图和应变率成像研究。
Eur Heart J. 2006 Nov;27(22):2689-95. doi: 10.1093/eurheartj/ehl163. Epub 2006 Aug 11.
8
Combined Circumferential and Longitudinal Left Ventricular Systolic Dysfunction in Patients with Rheumatoid Arthritis without Overt Cardiac Disease.类风湿关节炎无明显心脏病患者的左心室周向和纵向联合收缩功能障碍
J Am Soc Echocardiogr. 2016 Jul;29(7):689-98. doi: 10.1016/j.echo.2016.01.004. Epub 2016 Feb 24.
9
[Central hemodynamics in obesity].[肥胖中的中心血流动力学]
Ther Umsch. 2013 Feb;70(2):77-80. doi: 10.1024/0040-5930/a000368.
10
Obesity, heart failure and sudden death.肥胖、心力衰竭与猝死。
Nutr Metab Cardiovasc Dis. 2002 Aug;12(4):190-7.
引用本文的文献
1
Comparison of structural brain volume among sedentary normal, overweight and obese adults - A cross-sectional study.久坐不动的正常、超重和肥胖成年人脑结构体积比较——一项横断面研究。
J Educ Health Promot. 2025 Jul 31;14:297. doi: 10.4103/jehp.jehp_1396_24. eCollection 2025.
2
Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.用于心脏代谢疾病中器官间相互作用的多器官成像
Circ Res. 2025 May 23;136(11):1454-1475. doi: 10.1161/CIRCRESAHA.125.325517. Epub 2025 May 22.
3
Adiposity, fat-free mass and incident heart failure in 500 000 individuals.50 万人的肥胖程度、去脂体重与心力衰竭事件。
Open Heart. 2024 Jul 4;11(2):e002711. doi: 10.1136/openhrt-2024-002711.
4
The evaluation of bariatric surgery effect on cardiac structure and function using transthoracic echocardiography: a cohort study.使用经胸超声心动图评估减肥手术对心脏结构和功能的影响：一项队列研究。
BMC Surg. 2024 Jan 25;24(1):37. doi: 10.1186/s12893-024-02328-z.
5
Body Composition and Risk of Incident Heart Failure in 1 Million Adults: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.100 万成年人的身体成分与新发心力衰竭风险：系统评价和前瞻性队列研究的剂量-反应荟萃分析。
J Am Heart Assoc. 2023 Jul 4;12(13):e029062. doi: 10.1161/JAHA.122.029062. Epub 2023 Jun 22.
6
Relationship between overweight and obesity and cardiac dimensions and function in a paediatric population.儿童群体中超重及肥胖与心脏大小和功能之间的关系。
Eur J Pediatr. 2022 May;181(5):1943-1949. doi: 10.1007/s00431-022-04384-0. Epub 2022 Jan 25.
7
The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease.牛磺酸对心血管疾病的抗炎作用。
Nutrients. 2020 Sep 17;12(9):2847. doi: 10.3390/nu12092847.
8
The use of cardiovascular magnetic resonance for the assessment of left ventricular hypertrophy.心血管磁共振成像在评估左心室肥厚中的应用。
Cardiovasc Diagn Ther. 2020 Jun;10(3):568-582. doi: 10.21037/cdt.2020.01.14.
9
Obesity-related ventricular remodelling is exacerbated in dilated and hypertrophic cardiomyopathy.肥胖相关的心室重塑在扩张型和肥厚型心肌病中会加剧。
Cardiovasc Diagn Ther. 2020 Jun;10(3):559-567. doi: 10.21037/cdt-19-587.
10
Adenosine stress CMR T1-mapping detects early microvascular dysfunction in patients with type 2 diabetes mellitus without obstructive coronary artery disease.腺苷负荷心脏磁共振 T1 mapping 检测 2 型糖尿病无阻塞性冠状动脉疾病患者的早期微血管功能障碍。
J Cardiovasc Magn Reson. 2017 Oct 25;19(1):81. doi: 10.1186/s12968-017-0397-8.
本文引用的文献
1
Effects of weight loss on myocardial energetics and diastolic function in obesity.肥胖症患者体重减轻对心肌能量代谢和舒张功能的影响。
Int J Cardiovasc Imaging. 2013 Jun;29(5):1043-50. doi: 10.1007/s10554-012-0174-6. Epub 2012 Dec 27.
2
Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imaging.肥胖患者左心室重构的性别差异：心血管磁共振成像的见解。
Eur Heart J. 2013 Jan;34(4):292-9. doi: 10.1093/eurheartj/ehs341. Epub 2012 Oct 10.
3
Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial.SAVE 试验中减肥和减少胰岛素对动脉僵硬的影响。
Cardiovasc Diabetol. 2012 Sep 22;11:114. doi: 10.1186/1475-2840-11-114.
4
Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity.在健康受试者中增加血浆游离脂肪酸会引起肥胖患者中所见的主动脉顺应性变化。
Circ Cardiovasc Imaging. 2012 May 1;5(3):367-75. doi: 10.1161/CIRCIMAGING.111.971804. Epub 2012 Apr 5.
5
Effects of catecholamine stress on diastolic function and myocardial energetics in obesity.儿茶酚胺应激对肥胖患者舒张功能和心肌能量代谢的影响。
Circulation. 2012 Mar 27;125(12):1511-9. doi: 10.1161/CIRCULATIONAHA.111.069518. Epub 2012 Feb 24.
6
Prevalence of obesity and the relationship between the body mass index and body fat: cross-sectional, population-based data.肥胖症的流行情况以及体重指数与体脂之间的关系：基于人群的横断面数据。
PLoS One. 2012;7(1):e29580. doi: 10.1371/journal.pone.0029580. Epub 2012 Jan 13.
7
Morphological change of left atrium in obese individuals.肥胖个体左心房的形态学变化。
Int J Cardiol. 2011 Oct 6;152(1):117-9. doi: 10.1016/j.ijcard.2011.07.037. Epub 2011 Aug 5.
8
Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort.肥胖和超重对左心室舒张功能的影响：一项基于社区的老年队列研究。
J Am Coll Cardiol. 2011 Mar 22;57(12):1368-74. doi: 10.1016/j.jacc.2010.10.042.
9
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.高脂肪饮食可增加线粒体脂肪酸氧化和解偶联，降低大鼠心脏的效率。
Basic Res Cardiol. 2011 May;106(3):447-57. doi: 10.1007/s00395-011-0156-1. Epub 2011 Feb 12.
10
Body-mass index and mortality among 1.46 million white adults.146 万白人成年人的体重指数与死亡率。
N Engl J Med. 2010 Dec 2;363(23):2211-9. doi: 10.1056/NEJMoa1000367.
Zotero 插件