外周刺激治疗帕金森病：这是一个现实的想法还是浪漫的异想天开？
Peripheral stimulation in treating Parkinson's disease: Is it a realistic idea or a romantic whimsicality?
作者信息
Asakawa Tetsuya, Fang Huan, Hong Zhen, Sugiyama Kenji, Nozaki Takao, Namba Hiroki
机构信息
Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan;
Department of Pharmacy, Jinshan Hospital of Fudan University, Shanghai, China;
出版信息
Intractable Rare Dis Res. 2012 Nov;1(4):144-50. doi: 10.5582/irdr.2012.v1.4.144.
Parkinson's disease (PD) is a common, however, intractable neurodegenerative disorder in the aging population. Levodopa (l-dopa) administration is regarded as the most effective strategy in treating PD with prominent motor side-effects after undergoing long-term treatment. Surgical therapies such as deep brain stimulation (DBS) show certain efficacy, yet there are several limitations in adopting such surgical procedures. Therefore, performing electrical stimulation out of the brain, namely peripheral stimulation for PD has been a dream of many clinicians. Recently, the efficacy of dorsal column stimulation was verified in animal PD models; on the other hand, tons of acupunctural studies from East Asia claim good efficacy in treating PD both in bench and clinical studies. This review will introduce the progress of peripheral stimulation for PD, and will discuss the potential mechanisms involved in these strategies.
帕金森病（PD）是一种常见于老年人群的、难治性神经退行性疾病。左旋多巴（L-多巴）给药被认为是治疗帕金森病最有效的策略，但长期治疗后会出现明显的运动副作用。深部脑刺激（DBS）等手术疗法显示出一定疗效，但采用此类手术程序存在一些局限性。因此，在脑外进行电刺激，即对帕金森病进行外周刺激，一直是许多临床医生的梦想。最近，在动物帕金森病模型中证实了背柱刺激的疗效；另一方面，来自东亚的大量针灸研究表明，在基础研究和临床研究中，针灸治疗帕金森病均具有良好疗效。本综述将介绍帕金森病外周刺激的进展，并讨论这些策略所涉及的潜在机制。
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