Zhao Jun, Wallace Michael, Melancon Marites P
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Nanomedicine (Lond). 2014 Sep;9(13):2041-57. doi: 10.2217/nnm.14.136.
Gold nanoshells (AuNSs) present a vivid example of integrating nanoscience in order to solve a biomedical problem. AuNSs exhibit tunable surface plasmon resonance, which can be tuned to the near-infrared region in order to realize optimal tissue penetration. The highly efficient light-to-heat transformation by AuNSs during laser irradiation causes thermal damage to the tumor without damaging healthy organs. Transient nanobubbles can form around AuNSs during laser treatment and induce mechanical stress specifically in tumor cells. AuNSs also serve as a versatile platform for the delivery of various diagnostic and therapeutic agents. In this article, we describe the physicochemical properties of AuNSs in the context of their design, preparation and application in cancer theranostics. Ultimately, we look beyond the current research on AuNSs and discussed future challenges to their successful translation into clinical use.
金纳米壳（AuNSs）是将纳米科学整合以解决生物医学问题的一个生动例子。AuNSs表现出可调谐的表面等离子体共振，可将其调谐到近红外区域以实现最佳的组织穿透。在激光照射期间，AuNSs高效的光热转换会对肿瘤造成热损伤，而不会损害健康器官。在激光治疗期间，瞬态纳米气泡可在AuNSs周围形成，并特别在肿瘤细胞中诱导机械应力。AuNSs还作为用于递送各种诊断和治疗剂的通用平台。在本文中，我们在AuNSs的设计、制备及其在癌症诊疗中的应用背景下描述了其物理化学性质。最终，我们超越了目前对AuNSs的研究，并讨论了将其成功转化为临床应用所面临的未来挑战。
