Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Int J Mol Sci. 2024 Jan 29;25(3):1649. doi: 10.3390/ijms25031649.
Gold nanoshells have been actively applied in industries beyond the research stage because of their unique optical properties. Although numerous methods have been reported for gold nanoshell synthesis, the labor-intensive and time-consuming production process is an issue that must be overcome to meet industrial demands. To resolve this, we report a high-throughput synthesis method for nanogap-rich gold nanoshells based on a core silica support (denoted as SiO@Au NS), affording a 50-fold increase in scale by combining it with a dual-channel infusion pump system. By continuously dropping the reactant solution through the pump, nanoshells with closely packed Au nanoparticles were prepared without interparticle aggregation. The thickness of the gold nanoshells was precisely controlled at 2.3-17.2 nm by regulating the volume of the reactant solution added dropwise. Depending on the shell thickness, the plasmonic characteristics of SiO@Au NS prepared by the proposed method could be tuned. Moreover, SiO@Au NS exhibited surface-enhanced Raman scattering activity comparable to that of gold nanoshells prepared by a previously reported low-throughput method at the same reactant ratio. The results indicate that the proposed high-throughput synthesis method involving the use of a dual-channel infusion system will contribute to improving the productivity of SiO@Au NS with tunable plasmonic characteristics.
金纳米壳由于其独特的光学性质，已经在研究阶段之外的行业中得到了广泛的应用。尽管已经报道了许多金纳米壳的合成方法，但劳动密集型和耗时的生产过程是必须克服的问题，以满足工业需求。为了解决这个问题，我们报告了一种基于核硅基（表示为 SiO@Au NS）的高产量合成富含纳米间隙的金纳米壳的方法，通过与双通道输注泵系统相结合，规模增加了 50 倍。通过通过泵连续滴加反应物溶液，制备了没有颗粒间聚集的紧密堆积的 Au 纳米颗粒的纳米壳。通过调节添加的反应物溶液的体积，精确控制金纳米壳的厚度在 2.3-17.2nm 之间。根据壳的厚度，可以调整通过所提出的方法制备的 SiO@Au NS 的等离子体特性。此外，SiO@Au NS 表现出与以前报道的低产量方法在相同反应物比下制备的金纳米壳相当的表面增强拉曼散射活性。结果表明，涉及使用双通道输注系统的这种高通量合成方法将有助于提高具有可调等离子体特性的 SiO@Au NS 的生产率。
