Vigvári Szabolcs, Nemes Zsuzsanna, Vincze Aron, Solt Jenő, Sipos Dávid, Feiszt Zsófia, Kappéter Agnes, Kovács Beáta, Péterfi Zoltán
Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Infektológia munkacsoport, I. Belgyógyászati Klinika Pécs Ady E. u. 17. 7626.
Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Gasztroenterológia munkacsoport, I. Belgyógyászati Klinika Pécs.
Orv Hetil. 2014 Nov 2;155(44):1758-62. doi: 10.1556/OH.2014.30020.
During the past years a dramatic change has been observed in the epidemiology of Clostridium difficile infections.
The aim of the authors was to investigate the possibility of the fecal microbiota transplantation and study differences, if any, in the success rate of the two different upper gastrointestinal tract method.
100 ml of fecal microbiota solution was instilled via a nasoduodenal tube in 15 cases and a nasogastric tube in 15 cases. The authors defined the primary cure rate as the percentage of cases in which the symptoms disappeared without recurrence within 6 weeks after the first fecal microbiota transplantation, while secondary cure rate was calculated as the percentage of cases in which the symptoms resolved after the second fecal microbiota transplantation.
It was found that fecal microbiota transplantation applied via the nasoduodenal tube resulted in a 100% primary cure rate. With the use of the nasogastric tube, the primary and secondary cure rate were 80% and 93.3%, respectively. Fecal microbiota transplantation via the upper gastrointestinal tract was found to have an overall primary cure rate of 90.0% and a secondary cure rate of 96.7%.
Fecal microbiota transplantation proved to be very effective, particularly in recurrent infections and cases where conventional treatment failed.
在过去几年中，艰难梭菌感染的流行病学发生了显著变化。
作者旨在研究粪便微生物群移植的可能性，并研究两种不同上消化道方法成功率的差异（如有）。
15例通过鼻十二指肠管滴注100毫升粪便微生物群溶液，15例通过鼻胃管滴注。作者将初次治愈率定义为首次粪便微生物群移植后6周内症状消失且无复发的病例百分比，而二次治愈率计算为第二次粪便微生物群移植后症状缓解的病例百分比。
发现通过鼻十二指肠管进行粪便微生物群移植的初次治愈率为100%。使用鼻胃管时，初次治愈率和二次治愈率分别为80%和93.3%。通过上消化道进行粪便微生物群移植的总体初次治愈率为90.0%，二次治愈率为96.7%。
粪便微生物群移植被证明非常有效，特别是在复发性感染和传统治疗失败的病例中。
