Nagata Chisato, Konishi Kie, Tamura Takashi, Wada Keiko, Tsuji Michiko, Hayashi Makoto, Takeda Noriyuki, Yasuda Keigo
Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan. Department of Food and Nutrition, Japan Women's University, Tokyo, Japan.
Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):249-54. doi: 10.1158/1055-9965.EPI-14-0935. Epub 2014 Oct 28.
It has been hypothesized that alteration of hormone systems is involved in the carcinogenesis of acrylamide. The aim of the present study was to examine the cross-sectional associations between dietary acrylamide intake and sex hormone levels in premenopausal Japanese women.
Study subjects were 393 women who had regular menstrual cycles less than 40 days long. Acrylamide intake was assessed with a food-frequency questionnaire and was based on acrylamide concentration reported from analyses of Japanese foods. We measured the plasma concentrations of estradiol, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin, follicle-stimulating hormone, luteinizing hormone, and prolactin.
After controlling for age, the phase of the menstrual cycle, and other covariates, acrylamide intake was statistically significantly inversely associated with total and free estradiol levels and statistically significantly positively associated with follicle-stimulating hormone level. Total and free estradiol levels were 18.2% and 19.3% lower, respectively, in women in the highest quartile of acrylamide intake than in those in the lowest quartile of intake. Follicle-stimulating hormone levels were 23.5% higher in women in the highest quartile of acrylamide intake than in those in the lowest quartile of intake.
The data suggest that acrylamide intake may alter estradiol and follicle-stimulating hormone levels.
High estradiol levels have been associated with an increased risk of breast cancer. Although the results need confirmation, they highlight the need to investigate the relationships among dietary acrylamide, sex hormones, and breast cancer risk. Cancer Epidemiol Biomarkers Prev; 24(1); 249-54. ©2014 AACR.
有假设认为激素系统的改变与丙烯酰胺的致癌作用有关。本研究的目的是调查日本绝经前女性膳食丙烯酰胺摄入量与性激素水平之间的横断面关联。
研究对象为393名月经周期规律且少于40天的女性。通过食物频率问卷评估丙烯酰胺摄入量，该问卷基于对日本食物分析报告的丙烯酰胺浓度。我们测量了血浆中雌二醇、睾酮、硫酸脱氢表雄酮、性激素结合球蛋白、促卵泡激素、促黄体生成素和催乳素的浓度。
在控制年龄、月经周期阶段和其他协变量后，丙烯酰胺摄入量与总雌二醇和游离雌二醇水平呈统计学显著负相关，与促卵泡激素水平呈统计学显著正相关。丙烯酰胺摄入量处于最高四分位数的女性，其总雌二醇和游离雌二醇水平分别比摄入量处于最低四分位数的女性低18.2%和19.3%。丙烯酰胺摄入量处于最高四分位数的女性，其促卵泡激素水平比摄入量处于最低四分位数的女性高23.5%。
数据表明丙烯酰胺摄入量可能会改变雌二醇和促卵泡激素水平。
高雌二醇水平与乳腺癌风险增加有关。尽管结果需要证实，但它们凸显了调查膳食丙烯酰胺、性激素和乳腺癌风险之间关系的必要性。《癌症流行病学、生物标志物与预防》；24(1)；249 - 54。©2014美国癌症研究协会。
