Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zurich, Switzerland.
Chem Commun (Camb). 2014 Dec 21;50(98):15517-20. doi: 10.1039/c4cc07184k. Epub 2014 Oct 30.
A colorimetric probe for the detection of a mutagenic DNA adduct within a sequence was created. The probe involves incorporation of a synthetic nucleoside that selectively pairs opposite a target DNA adduct into oligonucleotides conjugated to gold nanoparticles (AuNPs).
创建了一种用于检测序列中致突变 DNA 加合物的比色探针。该探针涉及将一种合成核苷掺入到与金纳米粒子（AuNPs）缀合的寡核苷酸中，该核苷能够选择性地与靶 DNA 加合物配对。
