Blasco-Morente Gonzalo, Garrido-Colmenero Cristina, Pérez-López Israel, Carretero-García Simplicio, Martín-Castro Aurelio, Arias-Santiago Salvador, Tercedor-Sánchez Jesús
Department of Dermatology, Unit of the Virgen de las Nieves Hospital Complex, Granada, Spain.
J Cutan Pathol. 2015 Apr;42(4):253-7. doi: 10.1111/cup.12401. Epub 2015 Feb 3.
The assessment of discrepancies between surgical and histopathological measurements of specimens is important in order to avoid repeat surgery and unnecessary follow-ups.
The objective of this study was to quantify the degree, time and influential factors of shrinkage of cutaneous surgical specimens.
Data of 111 patients were gathered on age, sex, localization, diagnosis and specimen width and length before surgical excision (in vivo), at 5 min postsurgery (ex vivo) and after 24 h of fixation in 10% buffered formalin (postfixation).
The length and width were significantly lower in the postfixation vs. in vivo specimens, with a mean shrinkage of 17.0% in the length (p < 0.01) and 9.5% in the width (p < 0.01). 81.8% and 92.3% of the total shrinkage in length and weight was observed between in vivo and ex vivo measurements. No significant differences were observed as a function of sex, age or diagnosis. A greater shrinkage in length between in vivo and postfixation was found in specimens from the trunk.
The most of the skin samples were diseased.
The largest proportion of specimen shrinkage occurred within 5 min of its excision and the shrinkage was greater in specimens from the trunk.
评估手术标本与组织病理学测量之间的差异对于避免再次手术和不必要的随访很重要。
本研究的目的是量化皮肤手术标本收缩的程度、时间和影响因素。
收集了111例患者的年龄、性别、部位、诊断以及手术切除前（体内）、术后5分钟（体外）和在10%缓冲福尔马林中固定24小时后（固定后）标本的宽度和长度数据。
固定后标本的长度和宽度显著低于体内标本，长度平均收缩17.0%（p<0.01），宽度平均收缩9.5%（p<0.01）。在体内和体外测量之间，观察到长度和重量总收缩的81.8%和92.3%。未观察到性别、年龄或诊断方面的显著差异。躯干标本在体内和固定后之间的长度收缩更大。
大多数皮肤样本患病。
标本收缩的最大比例发生在切除后5分钟内，躯干标本的收缩更大。
