Mariani-Kurkdjian P, Lemaître C, Bidet P, Perez D, Boggini L, Kwon T, Bonacorsi S
Centre National de Référence associé Escherichia coli, Hôpital Robert-Debré, AP-HP Paris, France.
Centre National de Référence associé Escherichia coli, Hôpital Robert-Debré, AP-HP Paris, France ; IAME, UMR 1137, INSERM Paris, France ; IAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité Paris, France.
New Microbes New Infect. 2014 Jul;2(4):127-31. doi: 10.1002/nmi2.49. Epub 2014 May 27.
We describe a new atypical Shiga-toxin-producing Escherichia coli (STEC) responsible for a severe episode of haemolytic-uraemic syndrome in an adult with a relapse associated with bacteraemia. This STECs train of serotype O80:H2 harboured stx2c and stx2d gene subtypes, the rare eae ξ variant and a ColV plasmid with a conserved virulence plasmidic region involved in virulence of human and avian extraintestinal pathogenic E. coli. This atypical hybrid pathotype, which represents a new threat, is a further demonstration that STEC may be a recipient for extraintestinal virulence factors and raises again the question of antibiotic therapy during STEC infection.
我们描述了一种新型非典型产志贺毒素大肠杆菌（STEC），它导致一名成年人发生严重溶血尿毒综合征，并伴有与菌血症相关的复发。这种血清型为O80:H2的STEC菌株携带stx2c和stx2d基因亚型、罕见的eae ξ变体以及一个具有保守毒力质粒区域的ColV质粒，该区域与人和禽肠道外致病性大肠杆菌的毒力有关。这种非典型杂交致病型代表了一种新的威胁，进一步证明STEC可能是肠道外毒力因子的受体，并再次引发了STEC感染期间抗生素治疗的问题。
