Prouteau Antoinette, Atzeni Thierry, Tastet Hélène, Bergua Valérie, Destaillats Jean-Marc, Verdoux Hélène
a "Psychologie, Santé et Qualité de vie" , Univ Bordeaux , EA 4139, F-33000 , Bordeaux , France.
Cogn Neuropsychiatry. 2015;20(1):64-71. doi: 10.1080/13546805.2014.973486. Epub 2014 Oct 31.
This study explored whether integrity of executive functioning is required for good neurocognitive insight (NI) in subjects with schizophrenia.
NI was measured by subtracting executive difficulties (errors in the Modified Card Sorting Task) from executive cognitive complaints (Subjective Scale to Investigate Cognition in Schizophrenia) in 40 outpatients with schizophrenia and 42 normal controls. The schizophrenia sample was a priori divided into two subgroups on the basis of executive level. Multivariate analyses were conducted to compare groups and to control for potential confounding factors.
Only the schizophrenia dysexecutive subgroup had a poorer NI compared to normal controls. Group differences remained significant after adjustment for potential confounding factors (education, depression, anxiety and self-esteem).
These results provide support for the hypothesis that executive dysfunctioning is a limiting factor for NI, independently from depressive and anxiety symptoms.
本研究探讨了精神分裂症患者良好的神经认知洞察力（NI）是否需要执行功能的完整性。
通过从40例精神分裂症门诊患者和42例正常对照的执行认知主诉（精神分裂症认知调查主观量表）中减去执行困难（改良卡片分类任务中的错误）来测量NI。根据执行水平，将精神分裂症样本预先分为两个亚组。进行多变量分析以比较各组并控制潜在的混杂因素。
与正常对照相比，只有精神分裂症执行功能障碍亚组的NI较差。在对潜在的混杂因素（教育、抑郁、焦虑和自尊）进行调整后，组间差异仍然显著。
这些结果支持了这样一种假设，即执行功能障碍是NI的一个限制因素，与抑郁和焦虑症状无关。
