果蝇组蛋白基因重复单元中的tRNA衍生插入元件。
tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster.
作者信息
Matsuo Y, Yamazaki T
机构信息
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
出版信息
Nucleic Acids Res. 1989 Jan 11;17(1):225-38. doi: 10.1093/nar/17.1.225.
Abstract
Analysis of 41 histone homologous clones from an isogenic gene library of Drosophila melanogaster showed that non-histone fragments interrupt the histone repetitive clusters at several sites. Long (L) and short (S) forms of the repeating units are distinguished by the insertion of 240 bp into the spacer between H1 and H3 of the L units; Each form appears to be clustered with its own kind. The complete DNA sequence of the histone 5.0 kb repeating unit was determined. Five histone genes (H1, H2A, H2B, H3, H4) were identified in a repeating unit and several sequence blocks common to the five histone genes were found in the 5'- and 3'-regions. The insertion sequence of 240 bp was found to be similar to the Alu family, an element derived from tRNA.
摘要
对来自黑腹果蝇同基因文库的41个组蛋白同源克隆进行分析表明，非组蛋白片段在几个位点打断了组蛋白重复簇。重复单元的长（L）型和短（S）型通过在L单元的H1和H3之间的间隔区插入240 bp来区分；每种类型似乎都各自聚集在一起。测定了组蛋白5.0 kb重复单元的完整DNA序列。在一个重复单元中鉴定出五个组蛋白基因（H1、H2A、H2B、H3、H4），并且在5'和3'区域发现了这五个组蛋白基因共有的几个序列块。发现240 bp的插入序列与Alu家族相似，Alu家族是一种源自tRNA的元件。
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