Rashid Rehana, Mukhtar Farah, Khan Abida
Acta Pol Pharm. 2014 Sep-Oct;71(5):789-93.
This atudy was designed to evaluate the antifungal and cytotoxic activities of the Nannorrhops ritchiana (Mazari Palm) 80% methanol extract (NR-M) and its four crude extracts i.e., petroleum ether (NR-A), dichloromethane (NR-B), ethyl acetate (NR-C) and butanol (NR-D). The antifungal activity was determined by agar tube dilution method against nine fungal strains; Aspergillus flavus, Trichophyton longifusis, Trichophyton mentagrophytes, Aspergillus flavus and Microsporum canis were susceptible to the extracts with percentage inhibition of (70-80%). Extracts exhibited significant and good antifungal activity against various fungal strains. The results were deduced by comparing with those for miconazole, amphotericin B and ketoconazole as standard drugs. The fractions of methanolic extract were assayed for their brine shrimp cytotoxic activity. They exhibited low toxicity with LC50 values ranging from 285.7 to 4350.75 μg/mL at the concentration of obtained results warrant follow up through bioassay guided isolation of the active principles, future antiinfectious research.
本研究旨在评估里奇南椰枣（马扎里棕榈）80%甲醇提取物（NR-M）及其四种粗提物，即石油醚提取物（NR-A）、二氯甲烷提取物（NR-B）、乙酸乙酯提取物（NR-C）和正丁醇提取物（NR-D）的抗真菌和细胞毒性活性。采用琼脂试管稀释法测定了对九种真菌菌株的抗真菌活性；黄曲霉、长须毛癣菌、须癣毛癣菌、黄曲霉和犬小孢子菌对提取物敏感，抑制率为（70-80%）。提取物对各种真菌菌株均表现出显著且良好的抗真菌活性。通过与作为标准药物的咪康唑、两性霉素B和酮康唑的结果进行比较得出结果。对甲醇提取物的各部分进行了卤虫细胞毒性活性测定。它们表现出低毒性，在所得结果的浓度下，LC50值范围为285.7至4350.75μg/mL，有必要通过生物测定指导的活性成分分离、未来的抗感染研究进行后续跟进。
