基于高选择性合成方法的生物活性天然产物的全合成。
Total synthesis of biologically active natural products based on highly selective synthetic methodologies.
作者信息
Hatakeyama Susumi
机构信息
Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2014;62(11):1045-61. doi: 10.1248/cpb.c14-00474.
Total syntheses of structurally and biologically intriguing natural products relying on new synthetic methodologies are described. This article features cinchona alkaloid-catalyzed asymmetric Morita-Baylis-Hillman reactions, heterocycle syntheses based on rhodium-catalyzed C-H amination and indium-catalyzed Conia-ene reactions, and their utilization for the syntheses of the phoslactomycin family of antibiotics, glutamate receptor agonists and antagonists, and alkaloids with characteristic highly substituted pyrrolidinone core structures.
本文描述了依靠新的合成方法对结构和生物学上有趣的天然产物进行的全合成。本文重点介绍了金鸡纳生物碱催化的不对称森田-贝利斯-希尔曼反应、基于铑催化的C-H胺化反应和铟催化的科尼亚-烯反应的杂环合成，以及它们在抗生素磷霉素家族、谷氨酸受体激动剂和拮抗剂以及具有特征性高度取代吡咯烷酮核心结构的生物碱合成中的应用。
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