Soares J L M, Miot H A, Sanudo A, Bagatin E
Department of Dermatology, Federal University of Sao Paulo, UNIFESP, Sao Paulo, Brazil.
Int J Cosmet Sci. 2015 Feb;37(1):134-40. doi: 10.1111/ics.12177. Epub 2014 Nov 19.
Cellulite refers to skin relief alterations in women's thighs and buttocks, causing dissatisfaction and search for treatment. Its physiopathology is complex and not completely understood. Many therapeutic options have been reported with no scientific evidence about benefits. The majority of the studies are not controlled nor randomized; most efficacy endpoints are subjective, like not well-standardized photographs and investigator opinion. Objective measures could improve severity assessment. Our purpose was to correlate non-invasive instrumental measures and standardized clinical evaluation.
Twenty six women presenting cellulite on buttocks, aged from 25 to 41, were evaluated by: body mass index; standardized photography analysis (10-point severity and 5-point photonumeric scales) by five dermatologists; cutometry and high-frequency ultrasonography (dermal density and dermis/hypodermis interface length). Quality of life impact was assessed. Correlations between clinical and instrumental parameters were performed.
Good agreement among dermatologists and main investigator perceptions was detected. Positive correlations: body mass index and clinical scores; ultrasonographic measures. Negative correlation: cutometry and clinical scores. Quality of life score was correlated to dermal collagen density.
Cellulite caused impact in quality of life. Poor correlation between objective measures and clinical evaluation was detected. Cellulite severity assessment is a challenge, and objective parameters should be optimized for clinical trials.
橘皮组织指女性大腿和臀部皮肤外观的改变，这会导致她们不满并寻求治疗。其病理生理学复杂，尚未完全明晰。已有许多治疗方法被报道，但均缺乏有关疗效的科学证据。大多数研究未设对照，也未随机分组；多数疗效终点是主观的，如标准化程度欠佳的照片及研究者的观点。客观测量方法有助于改善严重程度评估。我们的目的是将非侵入性仪器测量与标准化临床评估相关联。
对26名年龄在25至41岁、臀部有橘皮组织的女性进行了评估，评估内容包括：体重指数；由五名皮肤科医生进行的标准化摄影分析（10分制严重程度评分和5分制光数字评分）；皮肤硬度测量法和高频超声检查（真皮密度和真皮/皮下组织界面长度）。评估了生活质量影响。对临床参数和仪器参数之间进行了相关性分析。
皮肤科医生与主要研究者的认知之间存在良好的一致性。正相关关系：体重指数与临床评分；超声测量结果。负相关关系：皮肤硬度测量法与临床评分。生活质量评分与真皮胶原蛋白密度相关。
橘皮组织对生活质量有影响。客观测量与临床评估之间的相关性较差。橘皮组织严重程度评估是一项挑战，客观参数应在临床试验中进行优化。
