Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco.
1] Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco. [2] University of California San Francisco and University of California Berkeley Joint Graduate Group in Bioengineering, San Francisco, California 94143, USA.
Nat Rev Mol Cell Biol. 2014 Dec;15(12):771-85. doi: 10.1038/nrm3902. Epub 2014 Nov 5.
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.
细胞外基质（ECM）的生化和生物物理特性决定了组织特异性的细胞行为。与每种组织的 ECM 相关的分子，包括胶原蛋白、蛋白聚糖、层粘连蛋白和纤连蛋白，以及它们的组装方式，决定了 ECM 的结构和组织。其结果是一种具有独特组成和拓扑特征的特定 ECM 特征，这些特征既反映又促进了组织的功能要求。
