胃旁路手术后与铜缺乏相关的视神经病变

Optic neuropathy associated with copper deficiency after gastric bypass surgery.

作者信息

Shah Ankoor R, Tamhankar Madhura A

机构信息

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

出版信息

Retin Cases Brief Rep. 2014 Winter;8(1):73-6. doi: 10.1097/ICB.0000000000000008.

Abstract

PURPOSE

Patients undergoing gastric bypass procedures are predisposed to many vitamin and mineral deficiencies including copper, which can lead to optic neuropathy.

METHODS

A 35-year-old woman complained of progressive vision loss bilaterally 3 years after gastric bypass surgery (GBS).

RESULTS

Ophthalmic examination revealed the presence of subnormal visual acuity and pale optic nerves bilaterally. Laboratory testing showed copper deficiency. Complete improvement in vision was noted after copper was replenished.

CONCLUSION

Nutritional deficiencies occurring after gastric bypass procedures are well reported. They happen and occur due to reduced gastric and enteral absorption and cause many systemic and neurologic manifestations. Optic neuropathy occurring after GBS is often due to vitamin B12 and folic acid deficiency. Copper deficiency causing systemic symptoms is very rare and usually takes decades to manifest. Our case is unique in that copper deficiency was noted as early as 3 years after GBS. Moreover rapid copper replenishment led to a dramatic recovery of vision. Our case underscores the need for maintaining high suspicion when evaluating patients with suspected optic neuropathy occurring after GBS since prompt diagnosis and treatment may lead to reversal of visual loss.

摘要

目的

接受胃旁路手术的患者易出现多种维生素和矿物质缺乏,包括铜缺乏,这可能导致视神经病变。

方法

一名35岁女性在胃旁路手术(GBS)3年后双侧渐进性视力丧失。

结果

眼科检查发现双侧视力低于正常且视神经苍白。实验室检查显示铜缺乏。补充铜后视力完全恢复。

结论

胃旁路手术后发生营养缺乏已有充分报道。它们是由于胃和肠道吸收减少而发生的,并引起许多全身和神经表现。GBS后发生的视神经病变通常是由于维生素B12和叶酸缺乏。导致全身症状的铜缺乏非常罕见,通常需要数十年才会显现。我们的病例很独特,因为早在GBS后3年就发现了铜缺乏。此外,快速补充铜导致视力显著恢复。我们的病例强调,在评估GBS后疑似视神经病变的患者时,需要高度怀疑,因为及时诊断和治疗可能导致视力丧失的逆转。

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