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1
Increased risk of preterm birth in singleton pregnancies after blastocyst versus Day 3 embryo transfer: Canadian ART Register (CARTR) analysis.囊胚培养与第 3 天胚胎移植后单胎妊娠早产风险增加：加拿大 ART 登记（CARTR）分析。
Hum Reprod. 2013 Apr;28(4):924-8. doi: 10.1093/humrep/des448. Epub 2013 Jan 24.
2
Extended embryo culture and an increased risk of preterm delivery.延长胚胎培养与早产风险增加。
Obstet Gynecol. 2012 Jul;120(1):69-75. doi: 10.1097/AOG.0b013e31825b88fc.
3
Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used.单胎妊娠的不良产科和围产期结局可能与与不孕相关的母体因素有关，而不是与所使用的辅助生殖技术类型有关。
Fertil Steril. 2012 Oct;98(4):922-8. doi: 10.1016/j.fertnstert.2012.05.049. Epub 2012 Jul 2.
4
Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis.体外受精治疗中冷冻解冻胚胎与新鲜胚胎移植后单胎妊娠的产科和围产结局：系统评价和荟萃分析。
Fertil Steril. 2012 Aug;98(2):368-77.e1-9. doi: 10.1016/j.fertnstert.2012.05.019. Epub 2012 Jun 13.
5
Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis.选择性单胚胎移植与围产结局：系统评价与荟萃分析。
Fertil Steril. 2012 Feb;97(2):324-31. doi: 10.1016/j.fertnstert.2011.11.033. Epub 2011 Dec 15.
6
Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses.体外受精单胎妊娠中的早产和低出生体重：系统评价和荟萃分析。
Eur J Obstet Gynecol Reprod Biol. 2009 Oct;146(2):138-48. doi: 10.1016/j.ejogrb.2009.05.035. Epub 2009 Jul 4.
7
Obstetric and neonatal outcome after single embryo transfer.单胚胎移植后的产科和新生儿结局
Hum Reprod. 2007 Apr;22(4):1073-9. doi: 10.1093/humrep/del492. Epub 2007 Jan 24.
8
The obstetrical and neonatal outcome of babies born after single-embryo transfer in IVF/ICSI compares favourably to spontaneously conceived babies.体外受精/卵胞浆内单精子注射（IVF/ICSI）后单胚胎移植出生的婴儿的产科和新生儿结局优于自然受孕的婴儿。
Hum Reprod. 2006 Apr;21(4):1041-6. doi: 10.1093/humrep/dei424. Epub 2006 Jan 20.
9
Consequences of vanishing twins in IVF/ICSI pregnancies.体外受精/卵胞浆内单精子注射妊娠中消失双胎的后果。
Hum Reprod. 2005 Oct;20(10):2821-9. doi: 10.1093/humrep/dei142. Epub 2005 Jun 24.
10
Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilization-embryo transfer or gamete intrafallopian transfer: a meta-analysis.体外受精-胚胎移植或配子输卵管内移植导致单胎妊娠早产风险增加：一项荟萃分析。
Fertil Steril. 2004 Dec;82(6):1514-20. doi: 10.1016/j.fertnstert.2004.06.038.

单胚胎移植对体外受精相关早产风险的影响。

Effect of single embryo transfer on the risk of preterm birth associated with in vitro fertilization.

作者信息

Fechner Adam J, Brown Kelecia R, Onwubalili Ndidiamaka, Jindal Sangita K, Weiss Gerson, Goldsmith Laura T, McGovern Peter G

机构信息

Department of Obstetrics, Gynecology and Women's Health, Rutgers-New Jersey Medical School, 185 South Orange Ave, MSB E506, Newark, NJ, 07103, USA,

出版信息

J Assist Reprod Genet. 2015 Feb;32(2):221-4. doi: 10.1007/s10815-014-0381-2. Epub 2014 Nov 6.

DOI:10.1007/s10815-014-0381-2
PMID:25374396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4354190/
Abstract

PURPOSE

To determine whether elective single embryo transfer (eSET) reduces the risk of preterm delivery associated with in vitro fertilization (IVF).

METHODS

This is an observational study of 3125 eSET cycles performed from 2008 to 2009 and reported to the Society for Assisted Reproductive Technology (SART) database. Preterm delivery rates were compared to the overall preterm delivery rate among all patients undergoing IVF over the same time period.

RESULTS

The 3125 eSET cycles resulted in 1507 live births (live birth rate 48.2 %) Among these deliveries were 27 twins (1.8 %) and one set of triplets (0.07 %). The overall preterm delivery rate (20-37 weeks gestation) following eSET was 17.6 % (269/1527). This is significantly greater than the preterm birth rate for all patients undergoing IVF over the same time period (12 %, P < 0.001).

CONCLUSIONS

Elective single embryo transfer does not reduce the risk of preterm delivery associated with in vitro fertilization (IVF).

摘要

目的

确定选择性单胚胎移植（eSET）是否能降低与体外受精（IVF）相关的早产风险。

方法

这是一项对2008年至2009年进行的3125个eSET周期的观察性研究，并报告给辅助生殖技术协会（SART）数据库。将早产率与同期所有接受IVF的患者的总体早产率进行比较。

结果

3125个eSET周期产生了1507例活产（活产率48.2%）。在这些分娩中，有27对双胞胎（1.8%）和一组三胞胎（0.07%）。eSET后的总体早产率（妊娠20 - 37周）为17.6%（269/1527）。这显著高于同期所有接受IVF的患者的早产率（12%，P < 0.001）。

结论

选择性单胚胎移植并不能降低与体外受精（IVF）相关的早产风险。