Egbe Thomas Obinchemti, Wafo Carine Youta, Bollo Berthe Bebey, Pany Christian, Onomo Monique Jong, Sandjon Guy
Faculty of Health Sciences, University of Buea, P.O. Box 63, Buea, Cameroon.
Department of Obstetrics and Gynecology Douala General Hospital, P.O. Box 4856, Douala, Cameroon.
Fertil Res Pract. 2016 Nov 21;2:12. doi: 10.1186/s40738-016-0028-3. eCollection 2016.
Premature Ovarian Insufficiency (POI) is classically defined as 4-6 months of cessation of menses (amenorrhea) in women under 40, associated with menopausal level of serum gonadotropins FSH > 40 IU/L and hypo-estrogenism and is also referred to as hypergonadotropic hypogonadism. This disorder can manifest as primary amenorrhea without the onset of menses (menarche), or as secondary amenorrhea after menarche and pubertal development. The diagnosis of this condition in Cameroon is sometimes difficult because of the high cost of hormonal assays and the few laboratories offering these services.
The patient was a 38-year-old G2P0020, blood group O Rh positive, genotype AA and BMI 19 kg/m2 who came to our service because of secondary amenorrhea and infertility of 2 years' duration. She has a history of pulmonary tuberculosis that was treated in Cameroon. After laparoscopy and hormonal profile, the diagnosis of premature ovarian insufficiency was reached. The woman underwent a successful donor egg in-vitro fertilization cycle and delivered a female fetus. Two years later YE requested IVF with autologous eggs, which was not possible, and since then she has remained with one child.
The diagnosis of premature ovarian insufficiency is difficult in Cameroon because of the high cost of laboratory investigations and difficult access to the tests. In-vitro fertilization with donor egg is a better treatment option. Unfortunately, it is not accessible to most Cameroonians because of lack of technical ability and the existence of cultural and financial barriers.
卵巢早衰（POI）的经典定义是40岁以下女性停经（闭经）4 - 6个月，伴有血清促性腺激素FSH > 40 IU/L的绝经水平和低雌激素血症，也被称为高促性腺激素性性腺功能减退。这种疾病可表现为原发性闭经（月经初潮未出现），或月经初潮及青春期发育后出现继发性闭经。在喀麦隆，由于激素检测成本高昂且提供此类服务的实验室较少，这种疾病的诊断有时会很困难。
患者为一名38岁女性，孕2产0，血型O型Rh阳性，基因型AA，体重指数19 kg/m²，因继发性闭经和2年不孕前来就诊。她有在喀麦隆接受过肺结核治疗的病史。经过腹腔镜检查和激素水平检测，诊断为卵巢早衰。该女性成功进行了供体卵子体外受精周期，并产下一名女婴。两年后，患者YE要求进行自体卵子体外受精，但未能成功，此后她仅育有一个孩子。
在喀麦隆，由于实验室检查成本高昂且难以获得检测服务，卵巢早衰的诊断较为困难。供体卵子体外受精是一种更好的治疗选择。不幸的是，由于缺乏技术能力以及存在文化和经济障碍，大多数喀麦隆人无法获得这种治疗。
