从溪黄草中分离得到的两种具有细胞毒性的6,7-断螺内酯-对映-贝壳杉烷型二萜类化合物。
Two cytotoxic 6,7-seco-spiro-lacton-ent-kauranoids from Isodon rubescens.
作者信息
Luo Guo-Yong, Deng Rui, Zhang Jing-Jie, Ye Jiang-Hai, Pan Lu-Tai
机构信息
a School of Pharmacy , Guiyang College of Traditional Chinese Medicine , Guiyang 550002 , China.
出版信息
J Asian Nat Prod Res. 2018 Mar;20(3):227-233. doi: 10.1080/10286020.2017.1317754. Epub 2017 Apr 24.
The present study was performed to investigate the chemical components of the branches and leaves of Isodon rubescens. Two 6,7-seco-spiro-lacton-ent-kauranoids were obtained. Based on the extensive spectroscopic analyses, their structures were elucidated as 6-epi-11-O-acetylangustifolin (1) and 11-O-acetylangustifolin (2), respectively. The structure of 2 was further comfirmed by X-ray crystallography analysis. MTT method was employed to evaluate their cytotoxity against human lung cancer cell lines A549 and leukemia cell lines K562.
本研究旨在调查冬凌草枝叶的化学成分。得到了两种6,7-断螺内酯-对映-贝壳杉烷型二萜类化合物。基于广泛的光谱分析，分别鉴定出它们的结构为6-表-11-O-乙酰基狭叶冬凌草素（1）和11-O-乙酰基狭叶冬凌草素（2）。通过X射线晶体学分析进一步确证了2的结构。采用MTT法评估它们对人肺癌细胞系A549和白血病细胞系K562的细胞毒性。
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