Radwan Michał, Jurewicz Joanna, Wielgomas Bartosz, Sobala Wojciech, Piskunowicz Marta, Radwan Paweł, Hanke Wojciech
From the Department of Gynecology and Reproduction (Dr Radwan, Dr Radwan); "Gameta" Hospital, Rzgów; Department of Environmental Epidemiology (Drs Jurewicz and Hanke, Mr Sobala), Nofer Institute of Occupational Medicine, Lodz; and Department of Toxicology (Dr Wielgomas, Ms Piskunowicz), Medical University of Gdańsk, Poland.
J Occup Environ Med. 2014 Nov;56(11):1113-9. doi: 10.1097/JOM.0000000000000297.
The aim of this study was to determine whether the environmental exposure to pyrethroids affects semen quality and the level of reproductive hormones in men.
The study population consisted of 334 men who attended the infertility clinic for diagnostic purposes and who had normal semen concentration of 15 to 300 mln/mL. Participants were interviewed and provided a semen sample. The pyrethroids metabolites-3-phenoxybenzoic acid (3PBA), cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (CDCCA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (TDCCA), and cis-2,2-dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA) were analyzed in the urine using a validated gas chromatography ion-trap mass spectrometry method.
Urinary pyrethroids metabolites levels were significantly associated with an increase in the percentage of sperm with abnormal morphology and decrease in sperm concentration, the level of testosterone, and computer-aided semen analysis parameters.
Environmental pyrethroids exposure may affect semen quality and the level of reproductive hormones.
本研究旨在确定拟除虫菊酯的环境暴露是否会影响男性的精液质量和生殖激素水平。
研究人群包括334名因诊断目的前往不孕不育门诊且精液浓度正常（15至300百万/mL）的男性。对参与者进行了访谈并采集了精液样本。采用经过验证的气相色谱离子阱质谱法分析尿液中的拟除虫菊酯代谢物——3-苯氧基苯甲酸（3PBA）、顺式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷羧酸（CDCCA）、反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷羧酸（TDCCA）和顺式-2,2-二溴乙烯基-2,2-二甲基环丙烷-1-羧酸（DBCA）。
尿液中拟除虫菊酯代谢物水平与形态异常精子百分比的增加、精子浓度的降低、睾酮水平以及计算机辅助精液分析参数显著相关。
环境中拟除虫菊酯暴露可能会影响精液质量和生殖激素水平。
