Zhang Rujing, Song Ziyuan, Yin Lichen, Zheng Nan, Tang Haoyu, Lu Hua, Gabrielson Nathan P, Lin Yao, Kim Kyung, Cheng Jianjun
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Jan-Feb;7(1):98-110. doi: 10.1002/wnan.1307. Epub 2014 Nov 6.
The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water-soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water-soluble α-helical ionic polypeptides originally developed in our laboratory and highlight their applications in cell membrane penetration and nonviral gene/small interfering RNA (siRNA) delivery.
高分子材料的出现显著推动了生物医学应用中各种技术的发展和快速增长，如组织工程以及可控药物和基因递送。带有功能性侧链并具有稳定二级结构的水溶性多肽是一类新型功能性高分子材料，在医学和生物技术领域具有潜在的广泛应用。在本文中，我们总结了我们实验室近期在水溶性α-螺旋离子多肽的设计与合成方面所做的工作，并重点介绍了它们在细胞膜穿透以及非病毒基因/小干扰RNA（siRNA）递送中的应用。
