Dobson Christopher M, Šali Andrej, Karplus Martin
Oxford Centre for Molecular Sciences, New Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QT (UK), Fax: (+44) 1-865-275-921.
The Rockefeller University, New York, NY (USA).
Angew Chem Int Ed Engl. 1998 Apr 20;37(7):868-893. doi: 10.1002/(SICI)1521-3773(19980420)37:7<868::AID-ANIE868>3.0.CO;2-H.
The mechanism of protein folding (represented schematically below) is one of the most fascinating problems in the field of chemical reactions. This review presents the progess made recently in understanding key elements of this reaction and describes a solution to the often quoted Levinthal Paradox.
蛋白质折叠机制(如下示意图所示)是化学反应领域中最引人入胜的问题之一。本综述介绍了近期在理解该反应关键要素方面取得的进展,并阐述了对常被提及的莱文索尔悖论的一种解决方案。