Lobet Sébastien, Hermans Cedric, Lambert Catherine
Hemostasis-Thrombosis Unit, Division of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium ; Division of Physical Medicine and Rehabilitation, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Hemostasis-Thrombosis Unit, Division of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
J Blood Med. 2014 Oct 17;5:207-18. doi: 10.2147/JBM.S50644. eCollection 2014.
Hemophilia is a hematological disorder characterized by a partial or complete deficiency of clotting factor VIII or IX. Its bleeding complications primarily affect the musculoskeletal system. Hemarthrosis is a major hemophilia-related complication, responsible for a particularly debilitating chronic arthropathy, in the long term. In addition to clotting factor concentrates, usually prescribed by the hematologist, managing acute hemarthrosis and chronic arthropathy requires a close collaboration between the orthopedic surgeon and physiotherapist. This collaboration, comprising a coagulation and musculoskeletal specialist, is key to effectively preventing hemarthrosis, managing acute joint bleeding episodes, assessing joint function, and actively treating chronic arthropathy. This paper reviews, from a practical point of view, the pathophysiology, clinical manifestations, and treatment of hemarthrosis and chronic hemophilia-induced arthropathy for hematologists, orthopedic surgeons, and physiotherapists.
血友病是一种血液系统疾病，其特征是凝血因子VIII或IX部分或完全缺乏。其出血并发症主要影响肌肉骨骼系统。关节积血是一种主要的血友病相关并发症，长期来看会导致特别使人衰弱的慢性关节病。除了血液科医生通常开具的凝血因子浓缩物外，处理急性关节积血和慢性关节病需要骨科医生和物理治疗师密切合作。这种由凝血和肌肉骨骼专家组成的合作对于有效预防关节积血、处理急性关节出血发作、评估关节功能以及积极治疗慢性关节病至关重要。本文从实际角度为血液科医生、骨科医生和物理治疗师综述了关节积血和慢性血友病性关节病的病理生理学、临床表现及治疗方法。
