Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Research and Development, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India.
J Tradit Complement Med. 2014 Oct;4(4):203-17. doi: 10.4103/2225-4110.139111.
Inflammatory bowel diseases (IBDs), consisting mainly of ulcerative colitis (UC) and Crohn's disease (CD), are important immune-mediated diseases of the gastrointestinal tract. The etiology of the disease includes environmental and genetic factors. Its management presents a constant challenge for gastroenterologists and conventional surgeon. 5-Amninosalicylates, antibiotics, steroids, and immune modulators have been used to reduce the symptoms and for maintenance of remission. Unfortunately, long-term usage of these agents has been found to lead to severe toxicities, which are deterrent to the users. Pre-clinical studies carried out in the recent past have shown that certain dietary agents, spices, oils, and dietary phytochemicals that are consumed regularly possess beneficial effects in preventing/ameliorating UC. For the first time, this review addresses the use of these dietary agents and spices in the treatment and prevention of IBD and also emphasizes on the mechanisms responsible for their effects.
炎症性肠病（IBD）主要包括溃疡性结肠炎（UC）和克罗恩病（CD），是一种重要的胃肠道免疫介导性疾病。其病因包括环境和遗传因素。这种疾病的治疗对胃肠病学家和普通外科医生来说是一个持续的挑战。5-氨基水杨酸、抗生素、类固醇和免疫调节剂已被用于减轻症状和维持缓解。不幸的是，这些药物的长期使用被发现会导致严重的毒性，这对使用者来说是一个阻碍。最近的临床前研究表明，某些饮食因子、香料、油和饮食植物化学物质经常被食用，对预防/缓解 UC 有有益的作用。这篇综述首次介绍了这些饮食因子和香料在治疗和预防 IBD 中的应用，并强调了它们作用的机制。
