自养在生命热力学极限下：产乙酸菌中能量守恒的模型。
Autotrophy at the thermodynamic limit of life: a model for energy conservation in acetogenic bacteria.
机构信息
Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
出版信息
Nat Rev Microbiol. 2014 Dec;12(12):809-21. doi: 10.1038/nrmicro3365. Epub 2014 Nov 10.
Life on earth evolved in the absence of oxygen with inorganic gases as potential sources of carbon and energy. Among the alternative mechanisms for carbon dioxide (CO₂) fixation in the living world, only the reduction of CO₂ by the Wood-Ljungdahl pathway, which is used by acetogenic bacteria, complies with the two requirements to sustain life: conservation of energy and production of biomass. However, how energy is conserved in acetogenic bacteria has been an enigma since their discovery. In this Review, we discuss the latest progress on the biochemistry and genetics of the energy metabolism of model acetogens, elucidating how these bacteria couple CO₂ fixation to energy conservation.
地球上的生命是在无氧环境中演化而来的，无机气体是潜在的碳和能源来源。在生命世界中，二氧化碳（CO₂）固定的替代机制中，只有产乙酸菌所利用的 Wood-Ljungdahl 途径能够还原 CO₂，同时满足维持生命的两个要求：能量守恒和生物质生产。然而，自从产乙酸菌被发现以来，它们如何进行能量守恒一直是个谜。在这篇综述中，我们讨论了模式产乙酸菌的能量代谢的生物化学和遗传学的最新进展，阐明了这些细菌如何将 CO₂固定与能量守恒相偶联。
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