Ulum Mokhamad F, Nasution Ahmad K, Yusop Abdul H, Arafat Andril, Kadir Mohammed Rafiq A, Juniantito Vetnizah, Noviana Deni, Hermawan Hendra
Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru, Malaysia.
Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.
J Biomed Mater Res B Appl Biomater. 2015 Oct;103(7):1354-65. doi: 10.1002/jbm.b.33315. Epub 2014 Nov 11.
Iron-bioceramic composites have been developed as biodegradable implant materials with tailored degradation behavior and bioactive features. In the current work, in vivo bioactivity of the composites was comprehensively studied by using sheep animal model. Five groups of specimens (Fe-HA, Fe-TCP, Fe-BCP composites, and pure-Fe and SS316L as controls) were surgically implanted into medio proximal region of the radial bones. Real-time ultrasound analysis showed a decreased echo pattern at the peri-implant biodegradation site of the composites indicating minimal tissue response during the wound healing process. Peripheral whole blood biomarkers monitoring showed a normal dynamic change of blood cellular responses and no stress effect was observed. Meanwhile, the released Fe ion concentration was increasing along the implantation period. Histological analysis showed that the composites corresponded with a lower inflammatory giant cell count than that of SS316L. Analysis of the retrieved implants showed a thicker degradation layer on the composites compared with pure-Fe. It can be concluded that the iron-bioceramic composites are bioactive and induce a preferable wound healing process.
铁生物陶瓷复合材料已被开发为具有定制降解行为和生物活性特征的可生物降解植入材料。在当前工作中，通过使用绵羊动物模型对复合材料的体内生物活性进行了全面研究。将五组标本（铁-羟基磷灰石、铁-磷酸三钙、铁-双相磷酸钙复合材料，以及作为对照的纯铁和316L不锈钢）手术植入桡骨的中近端区域。实时超声分析显示，复合材料植入周围的生物降解部位回声模式降低，表明在伤口愈合过程中组织反应最小。外周全血生物标志物监测显示血细胞反应呈正常动态变化，未观察到应激效应。同时，随着植入时间的延长，释放的铁离子浓度不断增加。组织学分析表明，与316L不锈钢相比，复合材料对应的炎性巨细胞计数更低。对取出的植入物进行分析发现，与纯铁相比，复合材料上的降解层更厚。可以得出结论，铁生物陶瓷复合材料具有生物活性，并能诱导较好的伤口愈合过程。
