Hermawan Hendra
Department of Mining, Metallurgical and Materials Engineering and CHU de Québec Research Center, Laval University, Quebec City, G1V 0A6, Canada.
Prog Biomater. 2018 Jun;7(2):93-110. doi: 10.1007/s40204-018-0091-4. Epub 2018 May 22.
Absorbable metals, metals that corrode in physiological environment, constitute a new class of biomaterials intended for temporary medical implant applications. The introduction of these metals has shifted the established paradigm of metal implants from preventing corrosion to its direct application. Interest toward absorbable metals has been growing in the past decade. This is proved by the rapid increase in scientific publication, progressive development of standards, and launching the first commercial products. Iron, magnesium, zinc, and their alloys are the current three absorbable metals families. Magnesium-based metals are the most progressing family with a large data set obtained from both basic and translational research. Iron-based metals are still facing a major challenge of low in vivo corrosion rate despite the significant efforts that have been put to overcome its weakness. Zinc-based metals are the new alternative absorbable metals with moderate corrosion rates that fall between those of iron and magnesium. This manuscript provides a brief review on the latest progress in the research and development of absorbable metals, the most important findings, the remaining challenges, and the perspective on the future direction.
可吸收金属，即在生理环境中会发生腐蚀的金属，构成了一类用于临时医疗植入应用的新型生物材料。这些金属的引入将金属植入物的既定范式从防止腐蚀转变为直接应用腐蚀。在过去十年中，人们对可吸收金属的兴趣不断增长。科学出版物的迅速增加、标准的逐步制定以及首批商业产品的推出都证明了这一点。铁、镁、锌及其合金是目前的三类可吸收金属。镁基金属是进展最为显著的一类，已经从基础研究和转化研究中获得了大量数据。尽管人们为克服铁基金属的弱点付出了巨大努力，但铁基金属在体内的腐蚀速率仍然很低，这仍是一个主要挑战。锌基金属是新型的可替代可吸收金属，其腐蚀速率适中，介于铁和镁之间。本文简要综述了可吸收金属研发的最新进展、最重要的研究发现、尚存的挑战以及未来的发展方向。
