Avian Disease and Oncology Laboratory, USDA, ARS, East Lansing, Michigan 48823; email:
Annu Rev Anim Biosci. 2013 Jan;1:239-60. doi: 10.1146/annurev-animal-031412-103701. Epub 2013 Jan 3.
The chicken has led the way among agricultural animal species in infectious disease control and, in particular, selection for genetic resistance. The generation of the chicken genome sequence and the availability of other empowering tools and resources greatly enhance the ability to select for enhanced disease resistance via genetic markers and to understand more deeply the biological basis of host resistance. In this review, we discuss how integrated genomic approaches are able to identify specific genes and genetic markers associated with disease resistance, give select examples of contemporary work involving various genomic strategies to identify disease resistance genes, and finish by giving some final thoughts on predicted applications in the near future.
在农业动物物种的传染病控制方面，鸡一直处于领先地位，特别是在遗传抗性方面的选择。鸡基因组序列的产生以及其他增强工具和资源的可用性极大地提高了通过遗传标记选择增强疾病抗性的能力，并更深入地了解宿主抗性的生物学基础。在这篇综述中，我们讨论了综合基因组方法如何能够识别与疾病抗性相关的特定基因和遗传标记，给出了涉及各种基因组策略来识别疾病抗性基因的当代工作的一些示例，并最后对不久的将来的预测应用进行了一些思考。
