Sinhabahu Vindika Prasad, Sathananthan Rajeev, Malavige Gathsaurie Neelika
Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Nugegoda, Sri Lanka.
BMC Res Notes. 2014 Nov 14;7:795. doi: 10.1186/1756-0500-7-795.
Dengue in pregnancy is associated with many maternal and foetal outcomes including perinatal transmission of dengue infection.
A baby was born by emergency caesarean section due to foetal distress and meconium stained liquor, to a 27-year old primi-gravidae, Sinhalese female, who was febrile during and 2 days prior to labour. The baby had evidence of respiratory distress due to meconium aspiration and was cared for in the special care baby unit for 3 days. On the 4th day he developed fever and serial blood counts showed a gradual rise in the haematocrit (>20% of baseline value) and lowering of platelet counts. The baby was treated for sepsis and as Sri Lanka was experiencing a massive dengue epidemic was also tested for dengue. His dengue NS1 antigen test was strongly positive and the dengue IgM antibodies weakly positive on day 3 of illness. The mother was positive for both dengue IgM and IgG antibodies.
Although rare, vertical transmission of the dengue virus has been reported and the baby most likely developed dengue due to perinatal transmission of dengue.
妊娠期登革热与许多母婴结局相关,包括登革热感染的围产期传播。
一名27岁的初产妇、僧伽罗族女性,因胎儿窘迫和羊水胎粪污染行急诊剖宫产分娩。该产妇在分娩期间及分娩前2天发热。婴儿因胎粪吸入出现呼吸窘迫,在新生儿特别护理病房接受了3天治疗。第4天,他出现发热,连续血常规检查显示血细胞比容逐渐升高(>基线值的20%),血小板计数降低。该婴儿接受了败血症治疗,由于斯里兰卡当时正在经历大规模登革热疫情,还对其进行了登革热检测。其登革热NS1抗原检测在发病第3天呈强阳性,登革热IgM抗体弱阳性。母亲的登革热IgM和IgG抗体均为阳性。
虽然罕见,但已有登革热病毒垂直传播的报道,该婴儿很可能因登革热的围产期传播而感染登革热。