Tu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam.
Department of High-Risk Pregnancy, Tu Du Hospital, Ho Chi Minh City, Vietnam.
Am J Trop Med Hyg. 2022 Nov 14;108(1):155-160. doi: 10.4269/ajtmh.22-0572. Print 2023 Jan 11.
Dengue hemorrhagic fever is a high-risk pathology in pregnancy, leading to an increased mortality rate for both the mother and baby. Perinatal transmission of dengue infection may occur during the labor stage of the febrile phase, despite its extreme rarity. In the present case, a young female patient with pregnancy at 39 weeks 3 days of gestational age was hospitalized because of dengue hemorrhagic fever. Upon monitoring, her platelet count gradually decreased to a very low of 13,000 mm3 on the third day of fever. However, her platelet count increased soon afterwards. On the eighth day of admission, she was delivered by emergency cesarean section due to acute fetal distress. The female neonate was promptly assessed by the pediatric team upon cesarean surgery. The neonate was diagnosed with vertical transmission of dengue infection based on positive dengue virus nonstructural protein 1 antigen, and low platelet count was found on the first day postpartum. When there is a high suspicion of perinatal transmission, closely monitoring the newborn helps to avoid the adverse outcomes and mortality for the infant. Herein, we thoroughly report an unusual case of maternal-fetal transmission of dengue during pregnancy at our maternity hospital.
登革出血热是妊娠的高危病理，会导致母亲和婴儿的死亡率增加。尽管极为罕见，但登革热感染可能会在发热期的分娩阶段进行围产期传播。在本病例中，一名年轻的女性患者在妊娠 39 周 3 天时因登革出血热住院。监测发现，她的血小板计数在发热的第三天逐渐降至非常低的 13,000/mm3。然而，随后她的血小板计数有所增加。入院第八天，她因急性胎儿窘迫而行紧急剖宫产。女婴在剖宫产手术时立即由儿科团队进行评估。根据登革病毒非结构蛋白 1 抗原阳性，新生儿被诊断为垂直传播登革感染，产后第一天发现血小板计数低。当高度怀疑围产期传播时，密切监测新生儿有助于避免婴儿出现不良后果和死亡。在此，我们彻底报告了我们妇产医院妊娠期间一例罕见的母婴传播登革热病例。
