Gross T P, Conde J G, Gary G W, Harting D, Goeller D, Israel E
Food and Drug Administration, Rockville, MD 20857.
Public Health Rep. 1989 Mar-Apr;104(2):164-9.
An outbreak of acute infectious nonbacterial gastroenteritis (AING) occurred in a high school in Maryland in 1984. Thirty-six percent of students surveyed met the case definition of gastroenteritis, as did 24 percent of school employees. Eating lunch in the cafeteria on January 30 was significantly associated with illness. After controlling for other food items consumed during the January 30 lunch, only the sandwiches were significantly associated with illness, but the source of the contamination was not identified. Four of 17 serum pairs from sick students and none of the 8 serum pairs from exposed controls (a nonsignificant difference) showed at least a 4-fold rise in antibody titre to Norwalk virus between acute- and convalescent-phase specimens. This outbreak of AING is believed to be the first to implicate epidemiologically sandwiches as vehicles of transmission. The outbreak highlights the need for investigators to look for a viral etiology in gastroenteritis outbreaks.
1984年,马里兰州的一所高中爆发了急性传染性非细菌性肠胃炎(AING)。接受调查的学生中有36%符合肠胃炎的病例定义,学校员工中这一比例为24%。1月30日在自助餐厅吃午餐与患病显著相关。在对1月30日午餐期间食用的其他食物进行控制后,只有三明治与患病显著相关,但污染来源未确定。17对患病学生的血清中有4对,8对暴露对照组的血清中无一例(差异不显著)在急性期和恢复期标本之间显示对诺如病毒的抗体滴度至少升高4倍。此次AING疫情被认为是首例在流行病学上表明三明治为传播媒介的疫情。该疫情凸显了调查人员在肠胃炎疫情中寻找病毒病因的必要性。